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The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?

Candida auris has become a major health threat due to its transmissibility, multidrug resistance and severe outcomes. In a case-control design, 74 hospitalised patients with candidemia were enrolled. In total, 22 cases (29.7%) and 52 controls (C. albicans, 21.6%; C. parapsilosis, 21.6%; C. tropicali...

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Autores principales: Alvarez-Moreno, Carlos A., Morales-López, Soraya, Rodriguez, Gerson J., Rodriguez, Jose Y., Robert, Estelle, Picot, Carine, Ceballos-Garzon, Andrés, Parra-Giraldo, Claudia M., Le Pape, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143486/
https://www.ncbi.nlm.nih.gov/pubmed/37108885
http://dx.doi.org/10.3390/jof9040430
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author Alvarez-Moreno, Carlos A.
Morales-López, Soraya
Rodriguez, Gerson J.
Rodriguez, Jose Y.
Robert, Estelle
Picot, Carine
Ceballos-Garzon, Andrés
Parra-Giraldo, Claudia M.
Le Pape, Patrice
author_facet Alvarez-Moreno, Carlos A.
Morales-López, Soraya
Rodriguez, Gerson J.
Rodriguez, Jose Y.
Robert, Estelle
Picot, Carine
Ceballos-Garzon, Andrés
Parra-Giraldo, Claudia M.
Le Pape, Patrice
author_sort Alvarez-Moreno, Carlos A.
collection PubMed
description Candida auris has become a major health threat due to its transmissibility, multidrug resistance and severe outcomes. In a case-control design, 74 hospitalised patients with candidemia were enrolled. In total, 22 cases (29.7%) and 52 controls (C. albicans, 21.6%; C. parapsilosis, 21.6%; C. tropicalis, 21.6%; C. glabrata, 1.4%) were included and analysed in this study. Risk factors, clinical and microbiological characteristics and outcomes of patients with C. auris and non-auris Candida species (NACS) candidemia were compared. Previous fluconazole exposure was significantly higher in C. auris candidemia patients (OR 3.3; 1.15–9.5). Most C. auris isolates were resistant to fluconazole (86.3%) and amphotericin B (59%) whilst NACS isolates were generally susceptible. No isolates resistant to echinocandins were detected. The average time to start antifungal therapy was 3.6 days. Sixty-three (85.1%) patients received adequate antifungal therapy, without significant differences between the two groups. The crude mortality at 30 and 90 days of candidemia was up to 37.8% and 40.5%, respectively. However, there was no difference in mortality both at 30 and 90 days between the group with candidemia by C. auris (31.8%) and by NACS (42.3%) (OR 0.6; 95% IC 0.24–1.97) and 36.4% and 42.3% (0.77; 0.27–2.1), respectively. In this study, mortality due to candidemia between C. auris and NACS was similar. Appropriate antifungal therapy in both groups may have contributed to finding no differences in outcomes.
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spelling pubmed-101434862023-04-29 The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality? Alvarez-Moreno, Carlos A. Morales-López, Soraya Rodriguez, Gerson J. Rodriguez, Jose Y. Robert, Estelle Picot, Carine Ceballos-Garzon, Andrés Parra-Giraldo, Claudia M. Le Pape, Patrice J Fungi (Basel) Brief Report Candida auris has become a major health threat due to its transmissibility, multidrug resistance and severe outcomes. In a case-control design, 74 hospitalised patients with candidemia were enrolled. In total, 22 cases (29.7%) and 52 controls (C. albicans, 21.6%; C. parapsilosis, 21.6%; C. tropicalis, 21.6%; C. glabrata, 1.4%) were included and analysed in this study. Risk factors, clinical and microbiological characteristics and outcomes of patients with C. auris and non-auris Candida species (NACS) candidemia were compared. Previous fluconazole exposure was significantly higher in C. auris candidemia patients (OR 3.3; 1.15–9.5). Most C. auris isolates were resistant to fluconazole (86.3%) and amphotericin B (59%) whilst NACS isolates were generally susceptible. No isolates resistant to echinocandins were detected. The average time to start antifungal therapy was 3.6 days. Sixty-three (85.1%) patients received adequate antifungal therapy, without significant differences between the two groups. The crude mortality at 30 and 90 days of candidemia was up to 37.8% and 40.5%, respectively. However, there was no difference in mortality both at 30 and 90 days between the group with candidemia by C. auris (31.8%) and by NACS (42.3%) (OR 0.6; 95% IC 0.24–1.97) and 36.4% and 42.3% (0.77; 0.27–2.1), respectively. In this study, mortality due to candidemia between C. auris and NACS was similar. Appropriate antifungal therapy in both groups may have contributed to finding no differences in outcomes. MDPI 2023-03-31 /pmc/articles/PMC10143486/ /pubmed/37108885 http://dx.doi.org/10.3390/jof9040430 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Alvarez-Moreno, Carlos A.
Morales-López, Soraya
Rodriguez, Gerson J.
Rodriguez, Jose Y.
Robert, Estelle
Picot, Carine
Ceballos-Garzon, Andrés
Parra-Giraldo, Claudia M.
Le Pape, Patrice
The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
title The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
title_full The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
title_fullStr The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
title_full_unstemmed The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
title_short The Mortality Attributable to Candidemia in C. auris Is Higher than That in Other Candida Species: Myth or Reality?
title_sort mortality attributable to candidemia in c. auris is higher than that in other candida species: myth or reality?
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143486/
https://www.ncbi.nlm.nih.gov/pubmed/37108885
http://dx.doi.org/10.3390/jof9040430
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