Cargando…

Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

Natural moisturizing factor (NMF) includes several compounds in the stratum corneum (SC), among them, urocanic acid (UCA). Ultraviolet (UV) exposure turns the trans-UCA of the SC into its cis isomer. We investigated the impact of a topical emollient emulsion treatment on the UCA isomers of the SC ex...

Descripción completa

Detalles Bibliográficos
Autores principales: de Souza Neto, Alicio Vitorino, Balla, Débora Quintas, Candido, Thalita Marcilio, Rosado, Catarina, Baby, André Rolim, Pessoa, Fabiana Vieira Lima Solino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143511/
https://www.ncbi.nlm.nih.gov/pubmed/37109405
http://dx.doi.org/10.3390/life13040876
_version_ 1785033870262927360
author de Souza Neto, Alicio Vitorino
Balla, Débora Quintas
Candido, Thalita Marcilio
Rosado, Catarina
Baby, André Rolim
Pessoa, Fabiana Vieira Lima Solino
author_facet de Souza Neto, Alicio Vitorino
Balla, Débora Quintas
Candido, Thalita Marcilio
Rosado, Catarina
Baby, André Rolim
Pessoa, Fabiana Vieira Lima Solino
author_sort de Souza Neto, Alicio Vitorino
collection PubMed
description Natural moisturizing factor (NMF) includes several compounds in the stratum corneum (SC), among them, urocanic acid (UCA). Ultraviolet (UV) exposure turns the trans-UCA of the SC into its cis isomer. We investigated the impact of a topical emollient emulsion treatment on the UCA isomers of the SC exposed to artificial UV stress. Aliquots of emollient emulsion were applied in healthy subjects for 2 h on delimited areas of the volar forearm, then, the SC was removed by tape stripping. Tapes were irradiated in a solar simulator chamber and a high performance liquid chromatograph was used to quantify UCA isomers from stripped SC extract. The amount of both UCA isomers were almost twice higher in the SC treated with the emollient emulsion. We also observed that the UV irradiation elevated the amount of the cis/trans UCA ratio on the SC (non-treated and treated), suggesting that the emollient sample was not able to avoid the UCA isomerization. The in vivo tests corroborated with the UCA data obtained ex vivo, since we found an increase in the superficial skin hydration with respective reduction of the TEWL, probably occurring by the occlusion performed by the emollient emulsion containing 15.0% w/w of caprylic/capric triglyceride.
format Online
Article
Text
id pubmed-10143511
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101435112023-04-29 Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum de Souza Neto, Alicio Vitorino Balla, Débora Quintas Candido, Thalita Marcilio Rosado, Catarina Baby, André Rolim Pessoa, Fabiana Vieira Lima Solino Life (Basel) Communication Natural moisturizing factor (NMF) includes several compounds in the stratum corneum (SC), among them, urocanic acid (UCA). Ultraviolet (UV) exposure turns the trans-UCA of the SC into its cis isomer. We investigated the impact of a topical emollient emulsion treatment on the UCA isomers of the SC exposed to artificial UV stress. Aliquots of emollient emulsion were applied in healthy subjects for 2 h on delimited areas of the volar forearm, then, the SC was removed by tape stripping. Tapes were irradiated in a solar simulator chamber and a high performance liquid chromatograph was used to quantify UCA isomers from stripped SC extract. The amount of both UCA isomers were almost twice higher in the SC treated with the emollient emulsion. We also observed that the UV irradiation elevated the amount of the cis/trans UCA ratio on the SC (non-treated and treated), suggesting that the emollient sample was not able to avoid the UCA isomerization. The in vivo tests corroborated with the UCA data obtained ex vivo, since we found an increase in the superficial skin hydration with respective reduction of the TEWL, probably occurring by the occlusion performed by the emollient emulsion containing 15.0% w/w of caprylic/capric triglyceride. MDPI 2023-03-25 /pmc/articles/PMC10143511/ /pubmed/37109405 http://dx.doi.org/10.3390/life13040876 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
de Souza Neto, Alicio Vitorino
Balla, Débora Quintas
Candido, Thalita Marcilio
Rosado, Catarina
Baby, André Rolim
Pessoa, Fabiana Vieira Lima Solino
Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
title Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
title_full Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
title_fullStr Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
title_full_unstemmed Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
title_short Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
title_sort effect of an emollient emulsion containing 15.0% of caprylic/capric triglyceride on the urocanic acid of the stratum corneum
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143511/
https://www.ncbi.nlm.nih.gov/pubmed/37109405
http://dx.doi.org/10.3390/life13040876
work_keys_str_mv AT desouzanetoaliciovitorino effectofanemollientemulsioncontaining150ofcapryliccaprictriglycerideontheurocanicacidofthestratumcorneum
AT balladeboraquintas effectofanemollientemulsioncontaining150ofcapryliccaprictriglycerideontheurocanicacidofthestratumcorneum
AT candidothalitamarcilio effectofanemollientemulsioncontaining150ofcapryliccaprictriglycerideontheurocanicacidofthestratumcorneum
AT rosadocatarina effectofanemollientemulsioncontaining150ofcapryliccaprictriglycerideontheurocanicacidofthestratumcorneum
AT babyandrerolim effectofanemollientemulsioncontaining150ofcapryliccaprictriglycerideontheurocanicacidofthestratumcorneum
AT pessoafabianavieiralimasolino effectofanemollientemulsioncontaining150ofcapryliccaprictriglycerideontheurocanicacidofthestratumcorneum