Cargando…

Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany

(1) Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an important β-hemolytic pathogen historically described as mainly affecting animals. Studies epidemiologically assessing the pathogenicity in the human population in Germany are rare. (2) Methods: the present study combines...

Descripción completa

Detalles Bibliográficos
Autores principales: Itzek, Andreas, Weißbach, Victoria, Meintrup, David, Rieß, Beate, van der Linden, Mark, Borgmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143538/
https://www.ncbi.nlm.nih.gov/pubmed/37111475
http://dx.doi.org/10.3390/pathogens12040589
_version_ 1785033876923482112
author Itzek, Andreas
Weißbach, Victoria
Meintrup, David
Rieß, Beate
van der Linden, Mark
Borgmann, Stefan
author_facet Itzek, Andreas
Weißbach, Victoria
Meintrup, David
Rieß, Beate
van der Linden, Mark
Borgmann, Stefan
author_sort Itzek, Andreas
collection PubMed
description (1) Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an important β-hemolytic pathogen historically described as mainly affecting animals. Studies epidemiologically assessing the pathogenicity in the human population in Germany are rare. (2) Methods: the present study combines national surveillance data from 2010 to 2022 with a single-center clinical study conducted from 2016 to 2022, focusing on emm type, Lancefield antigen, antimicrobial resistance, patient characteristics, disease severity, and clinical infection markers. (3) Results: The nationwide reported invasive SDSE infections suggest an increasing infection burden for the German population. One particular emm type, stG62647, increased over the study period, being the dominant type in both study cohorts, suggesting a mutation-driven outbreak of a virulent clone. The patient data show that men were more affected than women, although in the single-center cohort, this trend was reversed for patients with stG62647 SDSE. Men affected by stG62647 developed predominantly fascial infections, whereas women suffering from superficial and fascial non-stG62647 SDSE infections were significantly younger than other patients. Increasing age was a general risk factor for invasive SDSE infections. (4) Conclusions: further studies are needed to further elucidate the raised questions regarding outbreak origin, underlying molecular mechanisms as well as sex-dependent pathogen adaptation.
format Online
Article
Text
id pubmed-10143538
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101435382023-04-29 Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany Itzek, Andreas Weißbach, Victoria Meintrup, David Rieß, Beate van der Linden, Mark Borgmann, Stefan Pathogens Article (1) Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an important β-hemolytic pathogen historically described as mainly affecting animals. Studies epidemiologically assessing the pathogenicity in the human population in Germany are rare. (2) Methods: the present study combines national surveillance data from 2010 to 2022 with a single-center clinical study conducted from 2016 to 2022, focusing on emm type, Lancefield antigen, antimicrobial resistance, patient characteristics, disease severity, and clinical infection markers. (3) Results: The nationwide reported invasive SDSE infections suggest an increasing infection burden for the German population. One particular emm type, stG62647, increased over the study period, being the dominant type in both study cohorts, suggesting a mutation-driven outbreak of a virulent clone. The patient data show that men were more affected than women, although in the single-center cohort, this trend was reversed for patients with stG62647 SDSE. Men affected by stG62647 developed predominantly fascial infections, whereas women suffering from superficial and fascial non-stG62647 SDSE infections were significantly younger than other patients. Increasing age was a general risk factor for invasive SDSE infections. (4) Conclusions: further studies are needed to further elucidate the raised questions regarding outbreak origin, underlying molecular mechanisms as well as sex-dependent pathogen adaptation. MDPI 2023-04-13 /pmc/articles/PMC10143538/ /pubmed/37111475 http://dx.doi.org/10.3390/pathogens12040589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Itzek, Andreas
Weißbach, Victoria
Meintrup, David
Rieß, Beate
van der Linden, Mark
Borgmann, Stefan
Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany
title Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany
title_full Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany
title_fullStr Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany
title_full_unstemmed Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany
title_short Epidemiological and Clinical Features of Streptococcus dysgalactiae ssp. equisimilis stG62647 and Other emm Types in Germany
title_sort epidemiological and clinical features of streptococcus dysgalactiae ssp. equisimilis stg62647 and other emm types in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143538/
https://www.ncbi.nlm.nih.gov/pubmed/37111475
http://dx.doi.org/10.3390/pathogens12040589
work_keys_str_mv AT itzekandreas epidemiologicalandclinicalfeaturesofstreptococcusdysgalactiaesspequisimilisstg62647andotheremmtypesingermany
AT weißbachvictoria epidemiologicalandclinicalfeaturesofstreptococcusdysgalactiaesspequisimilisstg62647andotheremmtypesingermany
AT meintrupdavid epidemiologicalandclinicalfeaturesofstreptococcusdysgalactiaesspequisimilisstg62647andotheremmtypesingermany
AT rießbeate epidemiologicalandclinicalfeaturesofstreptococcusdysgalactiaesspequisimilisstg62647andotheremmtypesingermany
AT vanderlindenmark epidemiologicalandclinicalfeaturesofstreptococcusdysgalactiaesspequisimilisstg62647andotheremmtypesingermany
AT borgmannstefan epidemiologicalandclinicalfeaturesofstreptococcusdysgalactiaesspequisimilisstg62647andotheremmtypesingermany