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Osteosarcoma: Current Concepts and Evolutions in Management Principles

Osteosarcoma is a rare malignancy arising from mesenchymal tissue, and represents the most common bone sarcoma. The management of osteosarcoma is challenging, and requires a multidisciplinary approach. In daily clinical practice, surgery, radiotherapy, and conventional chemotherapy constitute the th...

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Autores principales: Pilavaki, Pampina, Gahanbani Ardakani, Amir, Gikas, Panagiotis, Constantinidou, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143544/
https://www.ncbi.nlm.nih.gov/pubmed/37109122
http://dx.doi.org/10.3390/jcm12082785
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author Pilavaki, Pampina
Gahanbani Ardakani, Amir
Gikas, Panagiotis
Constantinidou, Anastasia
author_facet Pilavaki, Pampina
Gahanbani Ardakani, Amir
Gikas, Panagiotis
Constantinidou, Anastasia
author_sort Pilavaki, Pampina
collection PubMed
description Osteosarcoma is a rare malignancy arising from mesenchymal tissue, and represents the most common bone sarcoma. The management of osteosarcoma is challenging, and requires a multidisciplinary approach. In daily clinical practice, surgery, radiotherapy, and conventional chemotherapy constitute the therapeutic armamentarium against the disease. However, a significant number of patients with initially localized osteosarcoma will experience local or distant recurrence, and the prognosis for metastatic disease remains dismal. There is a pressing need to identify novel therapeutic strategies to better manage osteosarcoma and improve survival outcomes. In this study, we present recent advances in the therapeutic management of osteosarcoma, including surgical and medical advances. The role of immunotherapy (immune checkpoint inhibitors, adoptive cellular therapy, cancer vaccines) and other targeted therapies including tyrosine kinase inhibitors is discussed; however, additional studies are required to delineate their roles in clinical practice.
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spelling pubmed-101435442023-04-29 Osteosarcoma: Current Concepts and Evolutions in Management Principles Pilavaki, Pampina Gahanbani Ardakani, Amir Gikas, Panagiotis Constantinidou, Anastasia J Clin Med Review Osteosarcoma is a rare malignancy arising from mesenchymal tissue, and represents the most common bone sarcoma. The management of osteosarcoma is challenging, and requires a multidisciplinary approach. In daily clinical practice, surgery, radiotherapy, and conventional chemotherapy constitute the therapeutic armamentarium against the disease. However, a significant number of patients with initially localized osteosarcoma will experience local or distant recurrence, and the prognosis for metastatic disease remains dismal. There is a pressing need to identify novel therapeutic strategies to better manage osteosarcoma and improve survival outcomes. In this study, we present recent advances in the therapeutic management of osteosarcoma, including surgical and medical advances. The role of immunotherapy (immune checkpoint inhibitors, adoptive cellular therapy, cancer vaccines) and other targeted therapies including tyrosine kinase inhibitors is discussed; however, additional studies are required to delineate their roles in clinical practice. MDPI 2023-04-09 /pmc/articles/PMC10143544/ /pubmed/37109122 http://dx.doi.org/10.3390/jcm12082785 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pilavaki, Pampina
Gahanbani Ardakani, Amir
Gikas, Panagiotis
Constantinidou, Anastasia
Osteosarcoma: Current Concepts and Evolutions in Management Principles
title Osteosarcoma: Current Concepts and Evolutions in Management Principles
title_full Osteosarcoma: Current Concepts and Evolutions in Management Principles
title_fullStr Osteosarcoma: Current Concepts and Evolutions in Management Principles
title_full_unstemmed Osteosarcoma: Current Concepts and Evolutions in Management Principles
title_short Osteosarcoma: Current Concepts and Evolutions in Management Principles
title_sort osteosarcoma: current concepts and evolutions in management principles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143544/
https://www.ncbi.nlm.nih.gov/pubmed/37109122
http://dx.doi.org/10.3390/jcm12082785
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