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Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents

Human immunodeficiency virus (HIV) is a lentivirus that is transmissible through blood and other body fluids. During the late 1980s and early 1990s, an estimated 10,000 Romanian children were infected with HIV-1 subtype F nosocomially through contaminated needles and untested blood transfusions. Rom...

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Autores principales: Isac, Raluca, Costa, Rodica, Frandes, Mirela, Lazureanu, Voichita Elena, Stroescu, Ramona Florina, Steflea, Ruxandra Maria, Bagiu, Iulia-Cristina, Horhat, Florin George, Chicin, Gratiana Nicoleta, Roberta, Avram Cecilia, Cornelia, Pacurari Alina, Doros, Gabriela, Gafencu, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143557/
https://www.ncbi.nlm.nih.gov/pubmed/37109416
http://dx.doi.org/10.3390/life13040888
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author Isac, Raluca
Costa, Rodica
Frandes, Mirela
Lazureanu, Voichita Elena
Stroescu, Ramona Florina
Steflea, Ruxandra Maria
Bagiu, Iulia-Cristina
Horhat, Florin George
Chicin, Gratiana Nicoleta
Roberta, Avram Cecilia
Cornelia, Pacurari Alina
Doros, Gabriela
Gafencu, Mihai
author_facet Isac, Raluca
Costa, Rodica
Frandes, Mirela
Lazureanu, Voichita Elena
Stroescu, Ramona Florina
Steflea, Ruxandra Maria
Bagiu, Iulia-Cristina
Horhat, Florin George
Chicin, Gratiana Nicoleta
Roberta, Avram Cecilia
Cornelia, Pacurari Alina
Doros, Gabriela
Gafencu, Mihai
author_sort Isac, Raluca
collection PubMed
description Human immunodeficiency virus (HIV) is a lentivirus that is transmissible through blood and other body fluids. During the late 1980s and early 1990s, an estimated 10,000 Romanian children were infected with HIV-1 subtype F nosocomially through contaminated needles and untested blood transfusions. Romania was a special case in the global acquired immunodeficiency syndrome (AIDS) pandemic, displaying the largest population of HIV-infected children by parental transmission between 1987–1990. In total, 205 HIV-infected patients from the western part of Romania were analyzed in this retrospective study. Over 70% of them had experienced horizontal transmission from an unknown source, while vertical transmission was identified in only five cases. Most patients had a moderate to severe clinical manifestation of HIV infection, 77.56% had undergone antiretroviral (ARV) treatment, most of them (71.21%) had experienced no adverse reactions and many of those with HIV (90.73%) had an undetectable viral load. Renal impairment was detected in one third of patients (34.63%). Patients born before 1990, male patients, patients diagnosed with HIV before the age of 10, and those undernourished or with renal impairment had a shorter average survival time than the group born after 1990, female patients, patients receiving ARV treatment, patients with a normal body mass index (BMI) and those without renal impairment. Periodical monitoring of the estimated glomerular filtration rate (eGFR) level, as well as the detection of protein excretion, should be taken into consideration worldwide when monitoring HIV-positive patients; this in order to detect even asymptomatic chronic kidney disease (CKD), and to manage these patients and prolong their lives.
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spelling pubmed-101435572023-04-29 Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents Isac, Raluca Costa, Rodica Frandes, Mirela Lazureanu, Voichita Elena Stroescu, Ramona Florina Steflea, Ruxandra Maria Bagiu, Iulia-Cristina Horhat, Florin George Chicin, Gratiana Nicoleta Roberta, Avram Cecilia Cornelia, Pacurari Alina Doros, Gabriela Gafencu, Mihai Life (Basel) Article Human immunodeficiency virus (HIV) is a lentivirus that is transmissible through blood and other body fluids. During the late 1980s and early 1990s, an estimated 10,000 Romanian children were infected with HIV-1 subtype F nosocomially through contaminated needles and untested blood transfusions. Romania was a special case in the global acquired immunodeficiency syndrome (AIDS) pandemic, displaying the largest population of HIV-infected children by parental transmission between 1987–1990. In total, 205 HIV-infected patients from the western part of Romania were analyzed in this retrospective study. Over 70% of them had experienced horizontal transmission from an unknown source, while vertical transmission was identified in only five cases. Most patients had a moderate to severe clinical manifestation of HIV infection, 77.56% had undergone antiretroviral (ARV) treatment, most of them (71.21%) had experienced no adverse reactions and many of those with HIV (90.73%) had an undetectable viral load. Renal impairment was detected in one third of patients (34.63%). Patients born before 1990, male patients, patients diagnosed with HIV before the age of 10, and those undernourished or with renal impairment had a shorter average survival time than the group born after 1990, female patients, patients receiving ARV treatment, patients with a normal body mass index (BMI) and those without renal impairment. Periodical monitoring of the estimated glomerular filtration rate (eGFR) level, as well as the detection of protein excretion, should be taken into consideration worldwide when monitoring HIV-positive patients; this in order to detect even asymptomatic chronic kidney disease (CKD), and to manage these patients and prolong their lives. MDPI 2023-03-27 /pmc/articles/PMC10143557/ /pubmed/37109416 http://dx.doi.org/10.3390/life13040888 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Isac, Raluca
Costa, Rodica
Frandes, Mirela
Lazureanu, Voichita Elena
Stroescu, Ramona Florina
Steflea, Ruxandra Maria
Bagiu, Iulia-Cristina
Horhat, Florin George
Chicin, Gratiana Nicoleta
Roberta, Avram Cecilia
Cornelia, Pacurari Alina
Doros, Gabriela
Gafencu, Mihai
Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
title Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
title_full Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
title_fullStr Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
title_full_unstemmed Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
title_short Renal Impairment Impact and Survival Analysis in a Romanian Cohort of HIV-1(F1)-Infected Children and Adolescents
title_sort renal impairment impact and survival analysis in a romanian cohort of hiv-1(f1)-infected children and adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143557/
https://www.ncbi.nlm.nih.gov/pubmed/37109416
http://dx.doi.org/10.3390/life13040888
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