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Computer-Aided Directed Evolution Generates Novel AAV Variants with High Transduction Efficiency

Adeno-associated viruses (AAVs) have become safe and effective tools for therapeutic in vivo gene drug delivery. Among many AAV serotypes, AAV2 is the most well-characterized. Although many studies have been carried out on the engineering of the capsid VR-VIII region, few attempts have been made in...

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Detalles Bibliográficos
Autores principales:	Han, Zengpeng, Luo, Nengsong, Wang, Fei, Cai, Yuxiang, Yang, Xin, Feng, Weiwei, Zhu, Zhenxiang, Wang, Jie, Wu, Yang, Ye, Chaohui, Lin, Kunzhang, Xu, Fuqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143561/ https://www.ncbi.nlm.nih.gov/pubmed/37112829 http://dx.doi.org/10.3390/v15040848

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