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Pathologic Mechanisms of the Newcastle Disease Virus

Newcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide. Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment candidate. The pathogenic mechanism has intrigued the great curiosity of researchers, and advances in the last two decades...

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Autores principales: Zhang, Di, Ding, Zhuang, Xu, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143668/
https://www.ncbi.nlm.nih.gov/pubmed/37112843
http://dx.doi.org/10.3390/v15040864
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author Zhang, Di
Ding, Zhuang
Xu, Xiaohong
author_facet Zhang, Di
Ding, Zhuang
Xu, Xiaohong
author_sort Zhang, Di
collection PubMed
description Newcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide. Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment candidate. The pathogenic mechanism has intrigued the great curiosity of researchers, and advances in the last two decades have been summarized in this paper. The NDV’s pathogenic ability is highly related to the basic protein structure of the virus, which is described in the Introduction of this review. The overall clinical signs and recent findings pertaining to NDV-related lymph tissue damage are then described. Given the involvement of cytokines in the overall virulence of NDV, cytokines, particularly IL6 and IFN expressed during infection, are reviewed. On the other hand, the host also has its way of antagonizing the virus, which starts with the detection of the pathogen. Thus, advances in NDV’s physiological cell mechanism and the subsequent IFN response, autophagy, and apoptosis are summarized to provide a whole picture of the NDV infection process.
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spelling pubmed-101436682023-04-29 Pathologic Mechanisms of the Newcastle Disease Virus Zhang, Di Ding, Zhuang Xu, Xiaohong Viruses Review Newcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide. Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment candidate. The pathogenic mechanism has intrigued the great curiosity of researchers, and advances in the last two decades have been summarized in this paper. The NDV’s pathogenic ability is highly related to the basic protein structure of the virus, which is described in the Introduction of this review. The overall clinical signs and recent findings pertaining to NDV-related lymph tissue damage are then described. Given the involvement of cytokines in the overall virulence of NDV, cytokines, particularly IL6 and IFN expressed during infection, are reviewed. On the other hand, the host also has its way of antagonizing the virus, which starts with the detection of the pathogen. Thus, advances in NDV’s physiological cell mechanism and the subsequent IFN response, autophagy, and apoptosis are summarized to provide a whole picture of the NDV infection process. MDPI 2023-03-28 /pmc/articles/PMC10143668/ /pubmed/37112843 http://dx.doi.org/10.3390/v15040864 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Di
Ding, Zhuang
Xu, Xiaohong
Pathologic Mechanisms of the Newcastle Disease Virus
title Pathologic Mechanisms of the Newcastle Disease Virus
title_full Pathologic Mechanisms of the Newcastle Disease Virus
title_fullStr Pathologic Mechanisms of the Newcastle Disease Virus
title_full_unstemmed Pathologic Mechanisms of the Newcastle Disease Virus
title_short Pathologic Mechanisms of the Newcastle Disease Virus
title_sort pathologic mechanisms of the newcastle disease virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143668/
https://www.ncbi.nlm.nih.gov/pubmed/37112843
http://dx.doi.org/10.3390/v15040864
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