High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study

(1) Background: Spermidine is a biogenic polyamine that plays a crucial role in mammalian metabolism. As spermidine levels decline with age, spermidine supplementation is suggested to prevent or delay age-related diseases. However, valid pharmacokinetic data regarding spermidine remains lacking. The...

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Detalles Bibliográficos
Autores principales: Senekowitsch, Stefan, Wietkamp, Eliza, Grimm, Michael, Schmelter, Franziska, Schick, Philipp, Kordowski, Anna, Sina, Christian, Otzen, Hans, Weitschies, Werner, Smollich, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/
https://www.ncbi.nlm.nih.gov/pubmed/37111071
http://dx.doi.org/10.3390/nu15081852

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