Cargando…

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?

There is a need for innovative pharmaceutical intervention in light of the increasing prevalence of metabolic disease and cardiovascular disease. The kidneys’ sodium-glucose cotransporter 2 inhibitors (SGLT2) receptors are targeted to reduce glucose reabsorption by SGLT2. Patients with type 2 diabet...

Descripción completa

Detalles Bibliográficos
Autores principales: Andreea, Munteanu Madalina, Surabhi, Swarnkar, Razvan-Ionut, Popescu, Lucia, Ciobotaru, Camelia, Nicolae, Emil, Tufanoiu, Tiberiu, Nanea Ioan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143699/
https://www.ncbi.nlm.nih.gov/pubmed/37109700
http://dx.doi.org/10.3390/medicina59040742
_version_ 1785033916530294784
author Andreea, Munteanu Madalina
Surabhi, Swarnkar
Razvan-Ionut, Popescu
Lucia, Ciobotaru
Camelia, Nicolae
Emil, Tufanoiu
Tiberiu, Nanea Ioan
author_facet Andreea, Munteanu Madalina
Surabhi, Swarnkar
Razvan-Ionut, Popescu
Lucia, Ciobotaru
Camelia, Nicolae
Emil, Tufanoiu
Tiberiu, Nanea Ioan
author_sort Andreea, Munteanu Madalina
collection PubMed
description There is a need for innovative pharmaceutical intervention in light of the increasing prevalence of metabolic disease and cardiovascular disease. The kidneys’ sodium-glucose cotransporter 2 inhibitors (SGLT2) receptors are targeted to reduce glucose reabsorption by SGLT2. Patients with type 2 diabetes mellitus (T2DM) benefit the most from reduced blood glucose levels, although this is just one of the numerous physiological consequences. To establish existing understanding and possible advantages and risks for SGLT2 inhibitors in clinical practice, this article will explore the influence of SGLT2 inhibitors on six major organ systems. In addition, this literature review will discuss the benefits and potential drawbacks of SGLT2 inhibitors on various organ systems and their potential application in therapeutic settings.
format Online
Article
Text
id pubmed-10143699
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101436992023-04-29 Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits? Andreea, Munteanu Madalina Surabhi, Swarnkar Razvan-Ionut, Popescu Lucia, Ciobotaru Camelia, Nicolae Emil, Tufanoiu Tiberiu, Nanea Ioan Medicina (Kaunas) Review There is a need for innovative pharmaceutical intervention in light of the increasing prevalence of metabolic disease and cardiovascular disease. The kidneys’ sodium-glucose cotransporter 2 inhibitors (SGLT2) receptors are targeted to reduce glucose reabsorption by SGLT2. Patients with type 2 diabetes mellitus (T2DM) benefit the most from reduced blood glucose levels, although this is just one of the numerous physiological consequences. To establish existing understanding and possible advantages and risks for SGLT2 inhibitors in clinical practice, this article will explore the influence of SGLT2 inhibitors on six major organ systems. In addition, this literature review will discuss the benefits and potential drawbacks of SGLT2 inhibitors on various organ systems and their potential application in therapeutic settings. MDPI 2023-04-10 /pmc/articles/PMC10143699/ /pubmed/37109700 http://dx.doi.org/10.3390/medicina59040742 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Andreea, Munteanu Madalina
Surabhi, Swarnkar
Razvan-Ionut, Popescu
Lucia, Ciobotaru
Camelia, Nicolae
Emil, Tufanoiu
Tiberiu, Nanea Ioan
Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?
title Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?
title_full Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?
title_fullStr Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?
title_full_unstemmed Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?
title_short Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors: Harms or Unexpected Benefits?
title_sort sodium-glucose cotransporter 2 (sglt2) inhibitors: harms or unexpected benefits?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143699/
https://www.ncbi.nlm.nih.gov/pubmed/37109700
http://dx.doi.org/10.3390/medicina59040742
work_keys_str_mv AT andreeamunteanumadalina sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits
AT surabhiswarnkar sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits
AT razvanionutpopescu sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits
AT luciaciobotaru sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits
AT camelianicolae sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits
AT emiltufanoiu sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits
AT tiberiunaneaioan sodiumglucosecotransporter2sglt2inhibitorsharmsorunexpectedbenefits