Chiral Separation of Apremilast by Capillary Electrophoresis Using Succinyl-β-Cyclodextrin—Reversal of Enantiomer Elution Order by Cationic Capillary Coating

A stereospecific capillary electrophoresis method was developed for the separation of the novel, antipsoriatic agent, apremilast (APR). Six anionic cyclodextrin (CD) derivatives were screened for their ability to discriminate between the uncharged enantiomers. Only succinyl-β-CD (Succ-β-CD) presente...

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Detalles Bibliográficos
Autores principales: Szabó, Zoltán-István, Benkő, Beáta-Mária, Bartalis-Fábián, Ágnes, Iványi, Róbert, Varga, Erzsébet, Szőcs, Levente, Tóth, Gergő
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143784/
https://www.ncbi.nlm.nih.gov/pubmed/37110544
http://dx.doi.org/10.3390/molecules28083310

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