Cargando…

Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles

We report herein on a new platform for synthesizing stable, inert, and dispersible metal-free single-chain nanoparticles (SCNPs) via intramolecular metal-traceless azide–alkyne click chemistry. It is well known that SCNPs synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) often exper...

Descripción completa

Detalles Bibliográficos
Autores principales: Blázquez-Martín, Agustín, Ruiz-Bardillo, Ainara, Verde-Sesto, Ester, Iturrospe, Amaia, Arbe, Arantxa, Pomposo, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143805/
https://www.ncbi.nlm.nih.gov/pubmed/37110979
http://dx.doi.org/10.3390/nano13081394
_version_ 1785033945972211712
author Blázquez-Martín, Agustín
Ruiz-Bardillo, Ainara
Verde-Sesto, Ester
Iturrospe, Amaia
Arbe, Arantxa
Pomposo, José A.
author_facet Blázquez-Martín, Agustín
Ruiz-Bardillo, Ainara
Verde-Sesto, Ester
Iturrospe, Amaia
Arbe, Arantxa
Pomposo, José A.
author_sort Blázquez-Martín, Agustín
collection PubMed
description We report herein on a new platform for synthesizing stable, inert, and dispersible metal-free single-chain nanoparticles (SCNPs) via intramolecular metal-traceless azide–alkyne click chemistry. It is well known that SCNPs synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) often experience metal-induced aggregation issues during storage. Moreover, the presence of metal traces limits its use in a number of potential applications. To address these problems, we selected a bifunctional cross-linker molecule, sym-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD). DIBOD has two highly strained alkyne bonds that allow for the synthesis of metal-free SCNPs. We demonstrate the utility of this new approach by synthesizing metal-free polystyrene (PS)-SCNPs without significant aggregation issues during storage, as demonstrated by small-angle X-ray scattering (SAXS) experiments. Notably, this method paves the way for the synthesis of long-term-dispersible, metal-free SCNPs from potentially any polymer precursor decorated with azide functional groups.
format Online
Article
Text
id pubmed-10143805
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101438052023-04-29 Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles Blázquez-Martín, Agustín Ruiz-Bardillo, Ainara Verde-Sesto, Ester Iturrospe, Amaia Arbe, Arantxa Pomposo, José A. Nanomaterials (Basel) Article We report herein on a new platform for synthesizing stable, inert, and dispersible metal-free single-chain nanoparticles (SCNPs) via intramolecular metal-traceless azide–alkyne click chemistry. It is well known that SCNPs synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) often experience metal-induced aggregation issues during storage. Moreover, the presence of metal traces limits its use in a number of potential applications. To address these problems, we selected a bifunctional cross-linker molecule, sym-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD). DIBOD has two highly strained alkyne bonds that allow for the synthesis of metal-free SCNPs. We demonstrate the utility of this new approach by synthesizing metal-free polystyrene (PS)-SCNPs without significant aggregation issues during storage, as demonstrated by small-angle X-ray scattering (SAXS) experiments. Notably, this method paves the way for the synthesis of long-term-dispersible, metal-free SCNPs from potentially any polymer precursor decorated with azide functional groups. MDPI 2023-04-18 /pmc/articles/PMC10143805/ /pubmed/37110979 http://dx.doi.org/10.3390/nano13081394 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blázquez-Martín, Agustín
Ruiz-Bardillo, Ainara
Verde-Sesto, Ester
Iturrospe, Amaia
Arbe, Arantxa
Pomposo, José A.
Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
title Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
title_full Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
title_fullStr Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
title_full_unstemmed Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
title_short Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
title_sort toward long-term-dispersible, metal-free single-chain nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143805/
https://www.ncbi.nlm.nih.gov/pubmed/37110979
http://dx.doi.org/10.3390/nano13081394
work_keys_str_mv AT blazquezmartinagustin towardlongtermdispersiblemetalfreesinglechainnanoparticles
AT ruizbardilloainara towardlongtermdispersiblemetalfreesinglechainnanoparticles
AT verdesestoester towardlongtermdispersiblemetalfreesinglechainnanoparticles
AT iturrospeamaia towardlongtermdispersiblemetalfreesinglechainnanoparticles
AT arbearantxa towardlongtermdispersiblemetalfreesinglechainnanoparticles
AT pomposojosea towardlongtermdispersiblemetalfreesinglechainnanoparticles