Structural Adaptation of the Single-Stranded DNA-Binding Protein C-Terminal to DNA Metabolizing Partners Guides Inhibitor Design

Single-stranded DNA-binding protein (SSB) is a bacterial interaction hub and an appealing target for antimicrobial therapy. Understanding the structural adaptation of the disordered SSB C-terminus (SSB-Ct) to DNA metabolizing enzymes (e.g., ExoI and RecO) is essential for designing high-affinity SSB...

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Detalles Bibliográficos
Autores principales: Tököli, Attila, Bodnár, Brigitta, Bogár, Ferenc, Paragi, Gábor, Hetényi, Anasztázia, Bartus, Éva, Wéber, Edit, Hegedüs, Zsófia, Szabó, Zoltán, Kecskeméti, Gábor, Szakonyi, Gerda, Martinek, Tamás A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143822/
https://www.ncbi.nlm.nih.gov/pubmed/37111518
http://dx.doi.org/10.3390/pharmaceutics15041032

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