ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of I(Kr)

ABT-333 (dasabuvir) is an antiviral agent used in hepatitis C treatment. The molecule, similarly to some inhibitors of hERG channels, responsible for the delayed rectifier potassium current (I(Kr)), contains the methanesulfonamide group. Reduced I(Kr) current leads to long QT syndrome and early afte...

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Detalles Bibliográficos
Autores principales: Kovács, Zsigmond Máté, Óvári, József, Dienes, Csaba, Magyar, János, Bányász, Tamás, Nánási, Péter P., Horváth, Balázs, Feher, Adam, Varga, Zoltan, Szentandrássy, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143825/
https://www.ncbi.nlm.nih.gov/pubmed/37111245
http://dx.doi.org/10.3390/ph16040488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143825/
https://www.ncbi.nlm.nih.gov/pubmed/37111245
http://dx.doi.org/10.3390/ph16040488

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