Cargando…
Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasiti...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143871/ https://www.ncbi.nlm.nih.gov/pubmed/37111300 http://dx.doi.org/10.3390/ph16040543 |
_version_ | 1785033963273715712 |
---|---|
author | Gaona-López, Carlos Vazquez-Jimenez, Lenci K. Gonzalez-Gonzalez, Alonzo Delgado-Maldonado, Timoteo Ortiz-Pérez, Eyrá Nogueda-Torres, Benjamín Moreno-Rodríguez, Adriana Vázquez, Karina Saavedra, Emma Rivera, Gildardo |
author_facet | Gaona-López, Carlos Vazquez-Jimenez, Lenci K. Gonzalez-Gonzalez, Alonzo Delgado-Maldonado, Timoteo Ortiz-Pérez, Eyrá Nogueda-Torres, Benjamín Moreno-Rodríguez, Adriana Vázquez, Karina Saavedra, Emma Rivera, Gildardo |
author_sort | Gaona-López, Carlos |
collection | PubMed |
description | Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasitic diseases, strains resistant to routinely used drugs have been reported. In addition, many first-line drugs have adverse effects ranging from mild to severe, including potential carcinogenic effects. Therefore, new lead compounds are needed to combat these parasites. Although little has been studied regarding the epigenetic mechanisms in lower eukaryotes, it is believed that epigenetics plays an essential role in vital aspects of the organism, from controlling the life cycle to the expression of genes involved in pathogenicity. Therefore, using epigenetic targets to combat these parasites is foreseen as an area with great potential for development. This review summarizes the main known epigenetic mechanisms and their potential as therapeutics for a group of medically important protozoal parasites. Different epigenetic mechanisms are discussed, highlighting those that can be used for drug repositioning, such as histone post-translational modifications (HPTMs). Exclusive parasite targets are also emphasized, including the base J and DNA 6 mA. These two categories have the greatest potential for developing drugs to treat or eradicate these diseases. |
format | Online Article Text |
id | pubmed-10143871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101438712023-04-29 Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs Gaona-López, Carlos Vazquez-Jimenez, Lenci K. Gonzalez-Gonzalez, Alonzo Delgado-Maldonado, Timoteo Ortiz-Pérez, Eyrá Nogueda-Torres, Benjamín Moreno-Rodríguez, Adriana Vázquez, Karina Saavedra, Emma Rivera, Gildardo Pharmaceuticals (Basel) Review Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasitic diseases, strains resistant to routinely used drugs have been reported. In addition, many first-line drugs have adverse effects ranging from mild to severe, including potential carcinogenic effects. Therefore, new lead compounds are needed to combat these parasites. Although little has been studied regarding the epigenetic mechanisms in lower eukaryotes, it is believed that epigenetics plays an essential role in vital aspects of the organism, from controlling the life cycle to the expression of genes involved in pathogenicity. Therefore, using epigenetic targets to combat these parasites is foreseen as an area with great potential for development. This review summarizes the main known epigenetic mechanisms and their potential as therapeutics for a group of medically important protozoal parasites. Different epigenetic mechanisms are discussed, highlighting those that can be used for drug repositioning, such as histone post-translational modifications (HPTMs). Exclusive parasite targets are also emphasized, including the base J and DNA 6 mA. These two categories have the greatest potential for developing drugs to treat or eradicate these diseases. MDPI 2023-04-04 /pmc/articles/PMC10143871/ /pubmed/37111300 http://dx.doi.org/10.3390/ph16040543 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gaona-López, Carlos Vazquez-Jimenez, Lenci K. Gonzalez-Gonzalez, Alonzo Delgado-Maldonado, Timoteo Ortiz-Pérez, Eyrá Nogueda-Torres, Benjamín Moreno-Rodríguez, Adriana Vázquez, Karina Saavedra, Emma Rivera, Gildardo Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs |
title | Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs |
title_full | Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs |
title_fullStr | Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs |
title_full_unstemmed | Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs |
title_short | Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs |
title_sort | advances in protozoan epigenetic targets and their inhibitors for the development of new potential drugs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143871/ https://www.ncbi.nlm.nih.gov/pubmed/37111300 http://dx.doi.org/10.3390/ph16040543 |
work_keys_str_mv | AT gaonalopezcarlos advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT vazquezjimenezlencik advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT gonzalezgonzalezalonzo advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT delgadomaldonadotimoteo advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT ortizperezeyra advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT noguedatorresbenjamin advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT morenorodriguezadriana advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT vazquezkarina advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT saavedraemma advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs AT riveragildardo advancesinprotozoanepigenetictargetsandtheirinhibitorsforthedevelopmentofnewpotentialdrugs |