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Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs

Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasiti...

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Autores principales: Gaona-López, Carlos, Vazquez-Jimenez, Lenci K., Gonzalez-Gonzalez, Alonzo, Delgado-Maldonado, Timoteo, Ortiz-Pérez, Eyrá, Nogueda-Torres, Benjamín, Moreno-Rodríguez, Adriana, Vázquez, Karina, Saavedra, Emma, Rivera, Gildardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143871/
https://www.ncbi.nlm.nih.gov/pubmed/37111300
http://dx.doi.org/10.3390/ph16040543
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author Gaona-López, Carlos
Vazquez-Jimenez, Lenci K.
Gonzalez-Gonzalez, Alonzo
Delgado-Maldonado, Timoteo
Ortiz-Pérez, Eyrá
Nogueda-Torres, Benjamín
Moreno-Rodríguez, Adriana
Vázquez, Karina
Saavedra, Emma
Rivera, Gildardo
author_facet Gaona-López, Carlos
Vazquez-Jimenez, Lenci K.
Gonzalez-Gonzalez, Alonzo
Delgado-Maldonado, Timoteo
Ortiz-Pérez, Eyrá
Nogueda-Torres, Benjamín
Moreno-Rodríguez, Adriana
Vázquez, Karina
Saavedra, Emma
Rivera, Gildardo
author_sort Gaona-López, Carlos
collection PubMed
description Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasitic diseases, strains resistant to routinely used drugs have been reported. In addition, many first-line drugs have adverse effects ranging from mild to severe, including potential carcinogenic effects. Therefore, new lead compounds are needed to combat these parasites. Although little has been studied regarding the epigenetic mechanisms in lower eukaryotes, it is believed that epigenetics plays an essential role in vital aspects of the organism, from controlling the life cycle to the expression of genes involved in pathogenicity. Therefore, using epigenetic targets to combat these parasites is foreseen as an area with great potential for development. This review summarizes the main known epigenetic mechanisms and their potential as therapeutics for a group of medically important protozoal parasites. Different epigenetic mechanisms are discussed, highlighting those that can be used for drug repositioning, such as histone post-translational modifications (HPTMs). Exclusive parasite targets are also emphasized, including the base J and DNA 6 mA. These two categories have the greatest potential for developing drugs to treat or eradicate these diseases.
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spelling pubmed-101438712023-04-29 Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs Gaona-López, Carlos Vazquez-Jimenez, Lenci K. Gonzalez-Gonzalez, Alonzo Delgado-Maldonado, Timoteo Ortiz-Pérez, Eyrá Nogueda-Torres, Benjamín Moreno-Rodríguez, Adriana Vázquez, Karina Saavedra, Emma Rivera, Gildardo Pharmaceuticals (Basel) Review Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasitic diseases, strains resistant to routinely used drugs have been reported. In addition, many first-line drugs have adverse effects ranging from mild to severe, including potential carcinogenic effects. Therefore, new lead compounds are needed to combat these parasites. Although little has been studied regarding the epigenetic mechanisms in lower eukaryotes, it is believed that epigenetics plays an essential role in vital aspects of the organism, from controlling the life cycle to the expression of genes involved in pathogenicity. Therefore, using epigenetic targets to combat these parasites is foreseen as an area with great potential for development. This review summarizes the main known epigenetic mechanisms and their potential as therapeutics for a group of medically important protozoal parasites. Different epigenetic mechanisms are discussed, highlighting those that can be used for drug repositioning, such as histone post-translational modifications (HPTMs). Exclusive parasite targets are also emphasized, including the base J and DNA 6 mA. These two categories have the greatest potential for developing drugs to treat or eradicate these diseases. MDPI 2023-04-04 /pmc/articles/PMC10143871/ /pubmed/37111300 http://dx.doi.org/10.3390/ph16040543 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gaona-López, Carlos
Vazquez-Jimenez, Lenci K.
Gonzalez-Gonzalez, Alonzo
Delgado-Maldonado, Timoteo
Ortiz-Pérez, Eyrá
Nogueda-Torres, Benjamín
Moreno-Rodríguez, Adriana
Vázquez, Karina
Saavedra, Emma
Rivera, Gildardo
Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
title Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
title_full Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
title_fullStr Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
title_full_unstemmed Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
title_short Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs
title_sort advances in protozoan epigenetic targets and their inhibitors for the development of new potential drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143871/
https://www.ncbi.nlm.nih.gov/pubmed/37111300
http://dx.doi.org/10.3390/ph16040543
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