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Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients

Background: Myocardial fibrosis represents a mainstay pathway in the pathophysiology of uremic cardiomyopathy. This process leads to structural and functional changes in the heart, which can be detected by echocardiography. The purpose of our study was to determine the association between four echoc...

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Autores principales: Ureche, Carina, Dodi, Gianina, Covic, Alexandra, Nedelcu, Alina, Volovăț, Simona R., Sascău, Radu A., Stătescu, Cristian, Covic, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143889/
https://www.ncbi.nlm.nih.gov/pubmed/37109335
http://dx.doi.org/10.3390/jcm12083003
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author Ureche, Carina
Dodi, Gianina
Covic, Alexandra
Nedelcu, Alina
Volovăț, Simona R.
Sascău, Radu A.
Stătescu, Cristian
Covic, Adrian
author_facet Ureche, Carina
Dodi, Gianina
Covic, Alexandra
Nedelcu, Alina
Volovăț, Simona R.
Sascău, Radu A.
Stătescu, Cristian
Covic, Adrian
author_sort Ureche, Carina
collection PubMed
description Background: Myocardial fibrosis represents a mainstay pathway in the pathophysiology of uremic cardiomyopathy. This process leads to structural and functional changes in the heart, which can be detected by echocardiography. The purpose of our study was to determine the association between four echocardiographic parameters (ejection fraction (EF), global longitudinal strain (GLS), mean E/e’ ratio, and left atrial volume indexed) and biomarkers associated with cardiac fibrosis, such as procollagen type I carboxy-terminal propeptide (PICP), procollagen type III N-terminal peptide (P3NP), and galectin-3 (Gal-3) in patients with end-stage renal disease (ESRD). Methods: 140 patients with ESRD were enrolled and investigated by echocardiography and the serum levels of the aforementioned biomarkers were determined at baseline. Results: The mean EF was 53.63 ± 8%, the mean GLS was −10.2 ± 5.3%, the mean E/e’ ratio was 9.8 ± 4.3, and the mean left atrial volume indexed (LAVI) was 45.8 ± 14.2 mL/m(2). The average levels for PICP, P3NP, and Gal-3 were 457.2 ± 240 µg/L, 242 ± 199.9 µg/L, and 10.7 ± 3.7 ng/mL, respectively. In regression analysis, PICP was strongly associated with all four echocardiographic parameters (EF: p = 0.0002, R(2) = 0.69; GLS: p = 0.00001, R(2) = 0.81; mean E/e’: p = 0.00002; R(2) = 0.89; LAVI: p = 0.003; R(2) = 0.73). P3NP and Gal-3 were only associated with the EF (p = 0.01, R(2) = 0.31 and p = 0.02; R(2) = 0.35, respectively). Conclusion: Our study evidenced that PICP, a collagen-derived biomarker, is associated with important echocardiography parameters, suggesting that it can serve as an indicator of the presence of subclinical systolic and diastolic dysfunction in patients with advanced CKD.
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spelling pubmed-101438892023-04-29 Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients Ureche, Carina Dodi, Gianina Covic, Alexandra Nedelcu, Alina Volovăț, Simona R. Sascău, Radu A. Stătescu, Cristian Covic, Adrian J Clin Med Article Background: Myocardial fibrosis represents a mainstay pathway in the pathophysiology of uremic cardiomyopathy. This process leads to structural and functional changes in the heart, which can be detected by echocardiography. The purpose of our study was to determine the association between four echocardiographic parameters (ejection fraction (EF), global longitudinal strain (GLS), mean E/e’ ratio, and left atrial volume indexed) and biomarkers associated with cardiac fibrosis, such as procollagen type I carboxy-terminal propeptide (PICP), procollagen type III N-terminal peptide (P3NP), and galectin-3 (Gal-3) in patients with end-stage renal disease (ESRD). Methods: 140 patients with ESRD were enrolled and investigated by echocardiography and the serum levels of the aforementioned biomarkers were determined at baseline. Results: The mean EF was 53.63 ± 8%, the mean GLS was −10.2 ± 5.3%, the mean E/e’ ratio was 9.8 ± 4.3, and the mean left atrial volume indexed (LAVI) was 45.8 ± 14.2 mL/m(2). The average levels for PICP, P3NP, and Gal-3 were 457.2 ± 240 µg/L, 242 ± 199.9 µg/L, and 10.7 ± 3.7 ng/mL, respectively. In regression analysis, PICP was strongly associated with all four echocardiographic parameters (EF: p = 0.0002, R(2) = 0.69; GLS: p = 0.00001, R(2) = 0.81; mean E/e’: p = 0.00002; R(2) = 0.89; LAVI: p = 0.003; R(2) = 0.73). P3NP and Gal-3 were only associated with the EF (p = 0.01, R(2) = 0.31 and p = 0.02; R(2) = 0.35, respectively). Conclusion: Our study evidenced that PICP, a collagen-derived biomarker, is associated with important echocardiography parameters, suggesting that it can serve as an indicator of the presence of subclinical systolic and diastolic dysfunction in patients with advanced CKD. MDPI 2023-04-20 /pmc/articles/PMC10143889/ /pubmed/37109335 http://dx.doi.org/10.3390/jcm12083003 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ureche, Carina
Dodi, Gianina
Covic, Alexandra
Nedelcu, Alina
Volovăț, Simona R.
Sascău, Radu A.
Stătescu, Cristian
Covic, Adrian
Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients
title Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients
title_full Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients
title_fullStr Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients
title_full_unstemmed Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients
title_short Connection between Cardiac Fibrosis Biomarkers and Echocardiography Parameters in Advanced Chronic Kidney Disease Patients
title_sort connection between cardiac fibrosis biomarkers and echocardiography parameters in advanced chronic kidney disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143889/
https://www.ncbi.nlm.nih.gov/pubmed/37109335
http://dx.doi.org/10.3390/jcm12083003
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