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Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment

(1) Background: Emerging data regarding patients recovered from COVID-19 are reported in the literature, but cardiac sequelae have not yet been clarified. To quickly detect any cardiac involvement at follow-up, the aims of the research were to identify: elements at admission predisposing subclinical...

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Autores principales: Cecchetto, Antonella, Torreggiani, Gianpaolo, Guarnieri, Gabriella, Vianello, Andrea, Baroni, Giulia, Palermo, Chiara, Bertagna De Marchi, Leonardo, Lorenzoni, Giulia, Bartolotta, Patrizia, Bertaglia, Emanuele, Donato, Filippo, Aruta, Patrizia, Iliceto, Sabino, Mele, Donato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144016/
https://www.ncbi.nlm.nih.gov/pubmed/37103058
http://dx.doi.org/10.3390/jcdd10040179
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author Cecchetto, Antonella
Torreggiani, Gianpaolo
Guarnieri, Gabriella
Vianello, Andrea
Baroni, Giulia
Palermo, Chiara
Bertagna De Marchi, Leonardo
Lorenzoni, Giulia
Bartolotta, Patrizia
Bertaglia, Emanuele
Donato, Filippo
Aruta, Patrizia
Iliceto, Sabino
Mele, Donato
author_facet Cecchetto, Antonella
Torreggiani, Gianpaolo
Guarnieri, Gabriella
Vianello, Andrea
Baroni, Giulia
Palermo, Chiara
Bertagna De Marchi, Leonardo
Lorenzoni, Giulia
Bartolotta, Patrizia
Bertaglia, Emanuele
Donato, Filippo
Aruta, Patrizia
Iliceto, Sabino
Mele, Donato
author_sort Cecchetto, Antonella
collection PubMed
description (1) Background: Emerging data regarding patients recovered from COVID-19 are reported in the literature, but cardiac sequelae have not yet been clarified. To quickly detect any cardiac involvement at follow-up, the aims of the research were to identify: elements at admission predisposing subclinical myocardial injury at follow up; the relationship between subclinical myocardial injury and multiparametric evaluation at follow-up; and subclinical myocardial injury longitudinal evolution. (2) Methods and Results: A total of 229 consecutive patients hospitalised for moderate to severe COVID-19 pneumonia were initially enrolled, of which 225 were available for follow-up. All patients underwent a first follow-up visit, which included a clinical evaluation, a laboratory test, echocardiography, a six-minute walking test (6MWT), and a pulmonary functional test. Of the 225 patients, 43 (19%) underwent a second follow-up visit. The median time to the first follow-up after discharge was 5 months, and the median time to the second follow-up after discharge was 12 months. Left ventricular global longitudinal strain (LVGLS) and right ventricular free wall strain (RVFWS) were reduced in 36% (n = 81) and 7.2% (n = 16) of the patients, respectively, at first the follow-up visit. LVGLS impairment showed correlations with patients of male gender (p 0.008, OR 2.32 (95% CI 1.24–4.42)), the presence of at least one cardiovascular risk factor (p < 0.001, OR 6.44 (95% CI 3.07–14.9)), and final oxygen saturation (p 0.002, OR 0.99 (95% CI 0.98–1)) for the 6MWTs. Subclinical myocardial dysfunction had not significantly improved at the 12-month follow-ups. (3) Conclusions: in patients recovered from COVID-19 pneumonia, left ventricular subclinical myocardial injury was related to cardiovascular risk factors and appeared stable during follow-up.
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spelling pubmed-101440162023-04-29 Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment Cecchetto, Antonella Torreggiani, Gianpaolo Guarnieri, Gabriella Vianello, Andrea Baroni, Giulia Palermo, Chiara Bertagna De Marchi, Leonardo Lorenzoni, Giulia Bartolotta, Patrizia Bertaglia, Emanuele Donato, Filippo Aruta, Patrizia Iliceto, Sabino Mele, Donato J Cardiovasc Dev Dis Article (1) Background: Emerging data regarding patients recovered from COVID-19 are reported in the literature, but cardiac sequelae have not yet been clarified. To quickly detect any cardiac involvement at follow-up, the aims of the research were to identify: elements at admission predisposing subclinical myocardial injury at follow up; the relationship between subclinical myocardial injury and multiparametric evaluation at follow-up; and subclinical myocardial injury longitudinal evolution. (2) Methods and Results: A total of 229 consecutive patients hospitalised for moderate to severe COVID-19 pneumonia were initially enrolled, of which 225 were available for follow-up. All patients underwent a first follow-up visit, which included a clinical evaluation, a laboratory test, echocardiography, a six-minute walking test (6MWT), and a pulmonary functional test. Of the 225 patients, 43 (19%) underwent a second follow-up visit. The median time to the first follow-up after discharge was 5 months, and the median time to the second follow-up after discharge was 12 months. Left ventricular global longitudinal strain (LVGLS) and right ventricular free wall strain (RVFWS) were reduced in 36% (n = 81) and 7.2% (n = 16) of the patients, respectively, at first the follow-up visit. LVGLS impairment showed correlations with patients of male gender (p 0.008, OR 2.32 (95% CI 1.24–4.42)), the presence of at least one cardiovascular risk factor (p < 0.001, OR 6.44 (95% CI 3.07–14.9)), and final oxygen saturation (p 0.002, OR 0.99 (95% CI 0.98–1)) for the 6MWTs. Subclinical myocardial dysfunction had not significantly improved at the 12-month follow-ups. (3) Conclusions: in patients recovered from COVID-19 pneumonia, left ventricular subclinical myocardial injury was related to cardiovascular risk factors and appeared stable during follow-up. MDPI 2023-04-19 /pmc/articles/PMC10144016/ /pubmed/37103058 http://dx.doi.org/10.3390/jcdd10040179 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cecchetto, Antonella
Torreggiani, Gianpaolo
Guarnieri, Gabriella
Vianello, Andrea
Baroni, Giulia
Palermo, Chiara
Bertagna De Marchi, Leonardo
Lorenzoni, Giulia
Bartolotta, Patrizia
Bertaglia, Emanuele
Donato, Filippo
Aruta, Patrizia
Iliceto, Sabino
Mele, Donato
Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment
title Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment
title_full Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment
title_fullStr Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment
title_full_unstemmed Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment
title_short Subclinical Myocardial Injury in Patients Recovered from COVID-19 Pneumonia: Predictors and Longitudinal Assessment
title_sort subclinical myocardial injury in patients recovered from covid-19 pneumonia: predictors and longitudinal assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144016/
https://www.ncbi.nlm.nih.gov/pubmed/37103058
http://dx.doi.org/10.3390/jcdd10040179
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