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The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human diseases. Considering this, the synthesis of napht...

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Autores principales: Navarro-Tovar, Gabriela, Vega-Rodríguez, Sarai, Leyva, Elisa, Loredo-Carrillo, Silvia, de Loera, Denisse, López-López, Lluvia Itzel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144089/
https://www.ncbi.nlm.nih.gov/pubmed/37111253
http://dx.doi.org/10.3390/ph16040496
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author Navarro-Tovar, Gabriela
Vega-Rodríguez, Sarai
Leyva, Elisa
Loredo-Carrillo, Silvia
de Loera, Denisse
López-López, Lluvia Itzel
author_facet Navarro-Tovar, Gabriela
Vega-Rodríguez, Sarai
Leyva, Elisa
Loredo-Carrillo, Silvia
de Loera, Denisse
López-López, Lluvia Itzel
author_sort Navarro-Tovar, Gabriela
collection PubMed
description Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human diseases. Considering this, the synthesis of naphthoquinone derivatives has been explored to contain compounds with potential biological activity. It has been reported that the chemical modification of naphthoquinones improves their pharmacological properties by introducing amines, amino acids, furan, pyran, pyrazole, triazole, indole, among other chemical groups. In this systematic review, we summarized the preparation of nitrogen naphthoquinones derivatives and discussed their biological effect associated with redox properties and other mechanisms. Preclinical evaluation of antibacterial and/or antitumoral naphthoquinones derivatives is included because cancer is a worldwide health problem, and there is a lack of effective drugs against multidrug-resistant bacteria. The information presented herein indicates that naphthoquinone derivatives could be considered for further studies to provide drugs efficient in treating cancer and multidrug-resistant bacteria.
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spelling pubmed-101440892023-04-29 The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review Navarro-Tovar, Gabriela Vega-Rodríguez, Sarai Leyva, Elisa Loredo-Carrillo, Silvia de Loera, Denisse López-López, Lluvia Itzel Pharmaceuticals (Basel) Review Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human diseases. Considering this, the synthesis of naphthoquinone derivatives has been explored to contain compounds with potential biological activity. It has been reported that the chemical modification of naphthoquinones improves their pharmacological properties by introducing amines, amino acids, furan, pyran, pyrazole, triazole, indole, among other chemical groups. In this systematic review, we summarized the preparation of nitrogen naphthoquinones derivatives and discussed their biological effect associated with redox properties and other mechanisms. Preclinical evaluation of antibacterial and/or antitumoral naphthoquinones derivatives is included because cancer is a worldwide health problem, and there is a lack of effective drugs against multidrug-resistant bacteria. The information presented herein indicates that naphthoquinone derivatives could be considered for further studies to provide drugs efficient in treating cancer and multidrug-resistant bacteria. MDPI 2023-03-27 /pmc/articles/PMC10144089/ /pubmed/37111253 http://dx.doi.org/10.3390/ph16040496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Navarro-Tovar, Gabriela
Vega-Rodríguez, Sarai
Leyva, Elisa
Loredo-Carrillo, Silvia
de Loera, Denisse
López-López, Lluvia Itzel
The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review
title The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review
title_full The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review
title_fullStr The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review
title_full_unstemmed The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review
title_short The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review
title_sort relevance and insights on 1,4-naphthoquinones as antimicrobial and antitumoral molecules: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144089/
https://www.ncbi.nlm.nih.gov/pubmed/37111253
http://dx.doi.org/10.3390/ph16040496
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