Cargando…

Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs

The 2018 United Nations High-Level Meeting on Tuberculosis (UNHLM) set targets for case detection and TB preventive treatment (TPT) by 2022. However, by the start of 2022, about 13.7 million TB patients still needed to be detected and treated, and 21.8 million household contacts needed to be given T...

Descripción completa

Detalles Bibliográficos
Autores principales: Satyanarayana, Srinath, Pretorius, Carel, Kanchar, Avinash, Garcia Baena, Ines, Den Boon, Saskia, Miller, Cecily, Zignol, Matteo, Kasaeva, Tereza, Falzon, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144108/
https://www.ncbi.nlm.nih.gov/pubmed/37104339
http://dx.doi.org/10.3390/tropicalmed8040214
_version_ 1785034022986973184
author Satyanarayana, Srinath
Pretorius, Carel
Kanchar, Avinash
Garcia Baena, Ines
Den Boon, Saskia
Miller, Cecily
Zignol, Matteo
Kasaeva, Tereza
Falzon, Dennis
author_facet Satyanarayana, Srinath
Pretorius, Carel
Kanchar, Avinash
Garcia Baena, Ines
Den Boon, Saskia
Miller, Cecily
Zignol, Matteo
Kasaeva, Tereza
Falzon, Dennis
author_sort Satyanarayana, Srinath
collection PubMed
description The 2018 United Nations High-Level Meeting on Tuberculosis (UNHLM) set targets for case detection and TB preventive treatment (TPT) by 2022. However, by the start of 2022, about 13.7 million TB patients still needed to be detected and treated, and 21.8 million household contacts needed to be given TPT globally. To inform future target setting, we examined how the 2018 UNHLM targets could have been achieved using WHO-recommended interventions for TB detection and TPT in 33 high-TB burden countries in the final year of the period covered by the UNHLM targets. We used OneHealth-TIME model outputs combined with the unit cost of interventions to derive the total costs of health services. Our model estimated that, in order to achieve UNHLM targets, >45 million people attending health facilities with symptoms would have needed to be evaluated for TB. An additional 23.1 million people with HIV, 19.4 million household TB contacts, and 303 million individuals from high-risk groups would have required systematic screening for TB. The estimated total costs amounted to ~USD 6.7 billion, of which ~15% was required for passive case finding, ~10% for screening people with HIV, ~4% for screening household contacts, ~65% for screening other risk groups, and ~6% for providing TPT to household contacts. Significant mobilization of additional domestic and international investments in TB healthcare services will be needed to reach such targets in the future.
format Online
Article
Text
id pubmed-10144108
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101441082023-04-29 Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs Satyanarayana, Srinath Pretorius, Carel Kanchar, Avinash Garcia Baena, Ines Den Boon, Saskia Miller, Cecily Zignol, Matteo Kasaeva, Tereza Falzon, Dennis Trop Med Infect Dis Article The 2018 United Nations High-Level Meeting on Tuberculosis (UNHLM) set targets for case detection and TB preventive treatment (TPT) by 2022. However, by the start of 2022, about 13.7 million TB patients still needed to be detected and treated, and 21.8 million household contacts needed to be given TPT globally. To inform future target setting, we examined how the 2018 UNHLM targets could have been achieved using WHO-recommended interventions for TB detection and TPT in 33 high-TB burden countries in the final year of the period covered by the UNHLM targets. We used OneHealth-TIME model outputs combined with the unit cost of interventions to derive the total costs of health services. Our model estimated that, in order to achieve UNHLM targets, >45 million people attending health facilities with symptoms would have needed to be evaluated for TB. An additional 23.1 million people with HIV, 19.4 million household TB contacts, and 303 million individuals from high-risk groups would have required systematic screening for TB. The estimated total costs amounted to ~USD 6.7 billion, of which ~15% was required for passive case finding, ~10% for screening people with HIV, ~4% for screening household contacts, ~65% for screening other risk groups, and ~6% for providing TPT to household contacts. Significant mobilization of additional domestic and international investments in TB healthcare services will be needed to reach such targets in the future. MDPI 2023-04-01 /pmc/articles/PMC10144108/ /pubmed/37104339 http://dx.doi.org/10.3390/tropicalmed8040214 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Satyanarayana, Srinath
Pretorius, Carel
Kanchar, Avinash
Garcia Baena, Ines
Den Boon, Saskia
Miller, Cecily
Zignol, Matteo
Kasaeva, Tereza
Falzon, Dennis
Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs
title Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs
title_full Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs
title_fullStr Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs
title_full_unstemmed Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs
title_short Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs
title_sort scaling up tb screening and tb preventive treatment globally: key actions and healthcare service costs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144108/
https://www.ncbi.nlm.nih.gov/pubmed/37104339
http://dx.doi.org/10.3390/tropicalmed8040214
work_keys_str_mv AT satyanarayanasrinath scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT pretoriuscarel scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT kancharavinash scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT garciabaenaines scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT denboonsaskia scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT millercecily scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT zignolmatteo scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT kasaevatereza scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts
AT falzondennis scalinguptbscreeningandtbpreventivetreatmentgloballykeyactionsandhealthcareservicecosts