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In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing

Rapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fittin...

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Autores principales: Liu, Shanfei, Wu, Guilin, Wang, Wen, Wang, Heng, Gao, Yingjun, Yang, Xuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144117/
https://www.ncbi.nlm.nih.gov/pubmed/37103380
http://dx.doi.org/10.3390/md21040241
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author Liu, Shanfei
Wu, Guilin
Wang, Wen
Wang, Heng
Gao, Yingjun
Yang, Xuhong
author_facet Liu, Shanfei
Wu, Guilin
Wang, Wen
Wang, Heng
Gao, Yingjun
Yang, Xuhong
author_sort Liu, Shanfei
collection PubMed
description Rapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fitting wounds with various sizes. Using an aqueous solvent overcame the disadvantage of using the current organic solvents as the medium for rapid wound dressings. The porous dressings had excellent air permeability to ensure smooth gas exchange at the wound site. The distribution range of the tensile strength of the dressings was 9–12 Kpa, and the tensile strain was between 60–80%, providing sufficient mechanical support during wound healing. The dressings could absorb 4–8 times their own weight in solution and could rapidly absorb wound exudates from wet wounds. The nanofibers formed ionic crosslinked hydrogel after absorbing exudates, maintaining the moist condition. It formed a hydrogel–nanofiber composite structure with un-gelled nanofibers and combined the photocrosslinking network to maintain a stable structure at the wound location. The in vitro cell culture assay indicated that the dressings had excellent cell cytocompatibility, and the addition of SF contributed to cell proliferation and wound healing. The in situ deposited nanofiber dressings had excellent potential in the urgent treatment of emergency wounds.
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spelling pubmed-101441172023-04-29 In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing Liu, Shanfei Wu, Guilin Wang, Wen Wang, Heng Gao, Yingjun Yang, Xuhong Mar Drugs Article Rapid wound dressings provide an excellent solution strategy for the treatment of wounds in emergency situations. In this study, aqueous solvent-based PVA/SF/SA/GelMA nanofiber dressings fabricated by a handheld electrospinning device could deposit quickly and directly on the wound, perfectly fitting wounds with various sizes. Using an aqueous solvent overcame the disadvantage of using the current organic solvents as the medium for rapid wound dressings. The porous dressings had excellent air permeability to ensure smooth gas exchange at the wound site. The distribution range of the tensile strength of the dressings was 9–12 Kpa, and the tensile strain was between 60–80%, providing sufficient mechanical support during wound healing. The dressings could absorb 4–8 times their own weight in solution and could rapidly absorb wound exudates from wet wounds. The nanofibers formed ionic crosslinked hydrogel after absorbing exudates, maintaining the moist condition. It formed a hydrogel–nanofiber composite structure with un-gelled nanofibers and combined the photocrosslinking network to maintain a stable structure at the wound location. The in vitro cell culture assay indicated that the dressings had excellent cell cytocompatibility, and the addition of SF contributed to cell proliferation and wound healing. The in situ deposited nanofiber dressings had excellent potential in the urgent treatment of emergency wounds. MDPI 2023-04-14 /pmc/articles/PMC10144117/ /pubmed/37103380 http://dx.doi.org/10.3390/md21040241 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Shanfei
Wu, Guilin
Wang, Wen
Wang, Heng
Gao, Yingjun
Yang, Xuhong
In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
title In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
title_full In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
title_fullStr In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
title_full_unstemmed In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
title_short In Situ Electrospinning of “Dry-Wet” Conversion Nanofiber Dressings for Wound Healing
title_sort in situ electrospinning of “dry-wet” conversion nanofiber dressings for wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144117/
https://www.ncbi.nlm.nih.gov/pubmed/37103380
http://dx.doi.org/10.3390/md21040241
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