Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery

Inhibition of ABC transporters is a promising approach to overcome multidrug resistance in cancer. Herein, we report the characterization of a potent ABCG2 inhibitor, namely, chromone 4a (C4a). Molecular docking and in vitro assays using ABCG2 and P-glycoprotein (P-gp) expressing membrane vesicles o...

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Detalles Bibliográficos
Autores principales: Valdameri, Glaucio, Kita, Diogo Henrique, Dutra, Julia de Paula, Gomes, Diego Lima, Tonduru, Arun Kumar, Kronenberger, Thales, Gavinho, Bruno, Rossi, Izadora Volpato, de Carvalho, Mariana Mazetto, Pérès, Basile, Zattoni, Ingrid Fatima, Rego, Fabiane Gomes de Moraes, Picheth, Geraldo, de Freitas, Rilton Alves, Poso, Antti, Ambudkar, Suresh V., Ramirez, Marcel I., Boumendjel, Ahcène, Moure, Vivian Rotuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144134/
https://www.ncbi.nlm.nih.gov/pubmed/37111745
http://dx.doi.org/10.3390/pharmaceutics15041259

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