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Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study

The efficacy of time-restricted eating for weight loss has not been established, as prior studies were limited by a lack of controlled isocaloric designs. This study describes the design and implementation of interventions in a controlled eating study evaluating time-restricted eating. We designed a...

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Autores principales: White, Karen, Wu, Beiwen, Pilla, Scott J., Charleston, Jeanne, Maw, May Thu Thu, Appel, Lawrence J., Clark, Jeanne M., Maruthur, Nisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144293/
https://www.ncbi.nlm.nih.gov/pubmed/37111198
http://dx.doi.org/10.3390/nu15081978
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author White, Karen
Wu, Beiwen
Pilla, Scott J.
Charleston, Jeanne
Maw, May Thu Thu
Appel, Lawrence J.
Clark, Jeanne M.
Maruthur, Nisa M.
author_facet White, Karen
Wu, Beiwen
Pilla, Scott J.
Charleston, Jeanne
Maw, May Thu Thu
Appel, Lawrence J.
Clark, Jeanne M.
Maruthur, Nisa M.
author_sort White, Karen
collection PubMed
description The efficacy of time-restricted eating for weight loss has not been established, as prior studies were limited by a lack of controlled isocaloric designs. This study describes the design and implementation of interventions in a controlled eating study evaluating time-restricted eating. We designed a randomized, controlled, parallel-arm eating study comparing time-restricted eating (TRE) to a usual eating pattern (UEP) for the primary outcome of weight change. Participants were aged 21–69 years with prediabetes and obesity. TRE consumed 80% of calories by 1300 h (military time), and UEP consumed ≥ 50% of calories after 1700 h (military time). Both arms consumed identical macro- and micro-nutrients based on a healthy, palatable diet. We calculated individual calorie requirements, which were maintained throughout the intervention. The desired distribution of calories across eating windows in both arms was achieved, as were the weekly averages for macronutrients and micronutrients. We actively monitored participants and adapted diets to facilitate adherence. We provide the first report, to our knowledge, on the design and implementation of eating study interventions that isolated the effect of meal timing on weight while maintaining constant caloric intake and identical diets during the study period.
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spelling pubmed-101442932023-04-29 Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study White, Karen Wu, Beiwen Pilla, Scott J. Charleston, Jeanne Maw, May Thu Thu Appel, Lawrence J. Clark, Jeanne M. Maruthur, Nisa M. Nutrients Article The efficacy of time-restricted eating for weight loss has not been established, as prior studies were limited by a lack of controlled isocaloric designs. This study describes the design and implementation of interventions in a controlled eating study evaluating time-restricted eating. We designed a randomized, controlled, parallel-arm eating study comparing time-restricted eating (TRE) to a usual eating pattern (UEP) for the primary outcome of weight change. Participants were aged 21–69 years with prediabetes and obesity. TRE consumed 80% of calories by 1300 h (military time), and UEP consumed ≥ 50% of calories after 1700 h (military time). Both arms consumed identical macro- and micro-nutrients based on a healthy, palatable diet. We calculated individual calorie requirements, which were maintained throughout the intervention. The desired distribution of calories across eating windows in both arms was achieved, as were the weekly averages for macronutrients and micronutrients. We actively monitored participants and adapted diets to facilitate adherence. We provide the first report, to our knowledge, on the design and implementation of eating study interventions that isolated the effect of meal timing on weight while maintaining constant caloric intake and identical diets during the study period. MDPI 2023-04-20 /pmc/articles/PMC10144293/ /pubmed/37111198 http://dx.doi.org/10.3390/nu15081978 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
White, Karen
Wu, Beiwen
Pilla, Scott J.
Charleston, Jeanne
Maw, May Thu Thu
Appel, Lawrence J.
Clark, Jeanne M.
Maruthur, Nisa M.
Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study
title Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study
title_full Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study
title_fullStr Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study
title_full_unstemmed Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study
title_short Design and Implementation of a Time-Restricted Eating Intervention in a Randomized, Controlled Eating Study
title_sort design and implementation of a time-restricted eating intervention in a randomized, controlled eating study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144293/
https://www.ncbi.nlm.nih.gov/pubmed/37111198
http://dx.doi.org/10.3390/nu15081978
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