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Antidiabetic Properties of Plant Secondary Metabolites

The prevalence of diabetes mellitus is one of the major medical problems that the modern world is currently facing. Type 1 and Type 2 diabetes mellitus both result in early disability and death, as well as serious social and financial problems. In some cases, synthetic drugs can be quite effective i...

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Autores principales: Sukhikh, Stanislav, Babich, Olga, Prosekov, Alexander, Kalashnikova, Olga, Noskova, Svetlana, Bakhtiyarova, Alina, Krol, Olesia, Tsvetkova, Elena, Ivanova, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144365/
https://www.ncbi.nlm.nih.gov/pubmed/37110171
http://dx.doi.org/10.3390/metabo13040513
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author Sukhikh, Stanislav
Babich, Olga
Prosekov, Alexander
Kalashnikova, Olga
Noskova, Svetlana
Bakhtiyarova, Alina
Krol, Olesia
Tsvetkova, Elena
Ivanova, Svetlana
author_facet Sukhikh, Stanislav
Babich, Olga
Prosekov, Alexander
Kalashnikova, Olga
Noskova, Svetlana
Bakhtiyarova, Alina
Krol, Olesia
Tsvetkova, Elena
Ivanova, Svetlana
author_sort Sukhikh, Stanislav
collection PubMed
description The prevalence of diabetes mellitus is one of the major medical problems that the modern world is currently facing. Type 1 and Type 2 diabetes mellitus both result in early disability and death, as well as serious social and financial problems. In some cases, synthetic drugs can be quite effective in the treatment of diabetes, though they have side effects. Plant-derived pharmacological substances are of particular interest. This review aims to study the antidiabetic properties of secondary plant metabolites. Existing review and research articles on the investigation of the antidiabetic properties of secondary plant metabolites, the methods of their isolation, and their use in diabetes mellitus, as well as separate articles that confirm the relevance of the topic and expand the understanding of the properties and mechanisms of action of plant metabolites, were analyzed for this review. The structure and properties of plants used for the treatment of diabetes mellitus, including plant antioxidants, polysaccharides, alkaloids, and insulin-like plant substances, as well as their antidiabetic properties and mechanisms for lowering blood sugar, are presented. The main advantages and disadvantages of using phytocomponents to treat diabetes are outlined. The types of complications of diabetes mellitus and the effects of medicinal plants and their phytocomponents on them are described. The effects of phytopreparations used to treat diabetes mellitus on the human gut microbiota are discussed. Plants with a general tonic effect, plants containing insulin-like substances, plants-purifiers, and plants rich in vitamins, organic acids, etc. have been shown to play an important role in the treatment of type 2 diabetes mellitus and the prevention of its complications.
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spelling pubmed-101443652023-04-29 Antidiabetic Properties of Plant Secondary Metabolites Sukhikh, Stanislav Babich, Olga Prosekov, Alexander Kalashnikova, Olga Noskova, Svetlana Bakhtiyarova, Alina Krol, Olesia Tsvetkova, Elena Ivanova, Svetlana Metabolites Review The prevalence of diabetes mellitus is one of the major medical problems that the modern world is currently facing. Type 1 and Type 2 diabetes mellitus both result in early disability and death, as well as serious social and financial problems. In some cases, synthetic drugs can be quite effective in the treatment of diabetes, though they have side effects. Plant-derived pharmacological substances are of particular interest. This review aims to study the antidiabetic properties of secondary plant metabolites. Existing review and research articles on the investigation of the antidiabetic properties of secondary plant metabolites, the methods of their isolation, and their use in diabetes mellitus, as well as separate articles that confirm the relevance of the topic and expand the understanding of the properties and mechanisms of action of plant metabolites, were analyzed for this review. The structure and properties of plants used for the treatment of diabetes mellitus, including plant antioxidants, polysaccharides, alkaloids, and insulin-like plant substances, as well as their antidiabetic properties and mechanisms for lowering blood sugar, are presented. The main advantages and disadvantages of using phytocomponents to treat diabetes are outlined. The types of complications of diabetes mellitus and the effects of medicinal plants and their phytocomponents on them are described. The effects of phytopreparations used to treat diabetes mellitus on the human gut microbiota are discussed. Plants with a general tonic effect, plants containing insulin-like substances, plants-purifiers, and plants rich in vitamins, organic acids, etc. have been shown to play an important role in the treatment of type 2 diabetes mellitus and the prevention of its complications. MDPI 2023-04-03 /pmc/articles/PMC10144365/ /pubmed/37110171 http://dx.doi.org/10.3390/metabo13040513 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sukhikh, Stanislav
Babich, Olga
Prosekov, Alexander
Kalashnikova, Olga
Noskova, Svetlana
Bakhtiyarova, Alina
Krol, Olesia
Tsvetkova, Elena
Ivanova, Svetlana
Antidiabetic Properties of Plant Secondary Metabolites
title Antidiabetic Properties of Plant Secondary Metabolites
title_full Antidiabetic Properties of Plant Secondary Metabolites
title_fullStr Antidiabetic Properties of Plant Secondary Metabolites
title_full_unstemmed Antidiabetic Properties of Plant Secondary Metabolites
title_short Antidiabetic Properties of Plant Secondary Metabolites
title_sort antidiabetic properties of plant secondary metabolites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144365/
https://www.ncbi.nlm.nih.gov/pubmed/37110171
http://dx.doi.org/10.3390/metabo13040513
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