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Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus

Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) infection. Drug-induced lupus (DIL) is a lupus-like disease caused by the intake of therapeutic drugs, which has been estimated to cause approximately 10–15%...

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Autores principales: Knudsen, Julie, Trier, Nicole Hartwig, Draborg, Anette Holck, Nielsen, Christoffer Tandrup, Jacobsen, Søren, Højrup, Peter, Houen, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144390/
https://www.ncbi.nlm.nih.gov/pubmed/37112967
http://dx.doi.org/10.3390/v15040986
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author Knudsen, Julie
Trier, Nicole Hartwig
Draborg, Anette Holck
Nielsen, Christoffer Tandrup
Jacobsen, Søren
Højrup, Peter
Houen, Gunnar
author_facet Knudsen, Julie
Trier, Nicole Hartwig
Draborg, Anette Holck
Nielsen, Christoffer Tandrup
Jacobsen, Søren
Højrup, Peter
Houen, Gunnar
author_sort Knudsen, Julie
collection PubMed
description Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) infection. Drug-induced lupus (DIL) is a lupus-like disease caused by the intake of therapeutic drugs, which has been estimated to cause approximately 10–15% of lupus-like cases. Although SLE and DIL share common clinical symptoms, there are some fundamental differences between DIL and SLE onset. Moreover, it remains to be examined whether environmental factors, such as EBV and CMV infections, may contribute to the development of DIL. This study focused on examining the possible association between DIL and EBV and CMV infections, by examining IgG titers to EBV and CMV antigens in serum samples by enzyme-linked immunosorbent assays. Antibody titers to EBV early antigen–diffuse and CMV pp52 were found to be significantly elevated in both SLE and DIL patients compared to healthy controls, although no correlation was found for antibodies to the two virus antigens in the respective disease groups. Moreover, total IgG titers were reduced in SLE and DIL serum samples, which may reflect a general lymphocytopenia, which commonly is associated with SLE. The current findings support that EBV and CMV infections may contribute to the development of DIL and that onset of both diseases are related.
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spelling pubmed-101443902023-04-29 Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus Knudsen, Julie Trier, Nicole Hartwig Draborg, Anette Holck Nielsen, Christoffer Tandrup Jacobsen, Søren Højrup, Peter Houen, Gunnar Viruses Article Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) infection. Drug-induced lupus (DIL) is a lupus-like disease caused by the intake of therapeutic drugs, which has been estimated to cause approximately 10–15% of lupus-like cases. Although SLE and DIL share common clinical symptoms, there are some fundamental differences between DIL and SLE onset. Moreover, it remains to be examined whether environmental factors, such as EBV and CMV infections, may contribute to the development of DIL. This study focused on examining the possible association between DIL and EBV and CMV infections, by examining IgG titers to EBV and CMV antigens in serum samples by enzyme-linked immunosorbent assays. Antibody titers to EBV early antigen–diffuse and CMV pp52 were found to be significantly elevated in both SLE and DIL patients compared to healthy controls, although no correlation was found for antibodies to the two virus antigens in the respective disease groups. Moreover, total IgG titers were reduced in SLE and DIL serum samples, which may reflect a general lymphocytopenia, which commonly is associated with SLE. The current findings support that EBV and CMV infections may contribute to the development of DIL and that onset of both diseases are related. MDPI 2023-04-17 /pmc/articles/PMC10144390/ /pubmed/37112967 http://dx.doi.org/10.3390/v15040986 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Knudsen, Julie
Trier, Nicole Hartwig
Draborg, Anette Holck
Nielsen, Christoffer Tandrup
Jacobsen, Søren
Højrup, Peter
Houen, Gunnar
Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus
title Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus
title_full Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus
title_fullStr Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus
title_full_unstemmed Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus
title_short Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus
title_sort elevated antibody titers to epstein–barr virus and cytomegalovirus in patients with drug-induced lupus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144390/
https://www.ncbi.nlm.nih.gov/pubmed/37112967
http://dx.doi.org/10.3390/v15040986
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