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Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion

Herpes simplex virus (HSV) requires four essential virion glycoproteins—gD, gH, gL, and gB—for virus entry and cell fusion. To initiate fusion, the receptor binding protein gD interacts with one of two major cell receptors, HVEM or nectin-1. Once gD binds to a receptor, fusion is carried out by the...

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Detalles Bibliográficos
Autores principales:	Atanasiu, Doina, Saw, Wan Ting, Cairns, Tina M., Friedman, Harvey M., Eisenberg, Roselyn J., Cohen, Gary H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144430/ https://www.ncbi.nlm.nih.gov/pubmed/37112875 http://dx.doi.org/10.3390/v15040895

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