Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent

LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluated, yielding IC(50) values of 0.06 and 0.07 μM, re...

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Detalles Bibliográficos
Autores principales: Guimarães, Celina de Jesus, Carneiro, Teiliane Rodrigues, Frederico, Marisa Jadna Silva, de Carvalho, Guilherme G. C., Little, Matthew, Freire, Valder N., França, Victor L. B., do Amaral, Daniel Nascimento, Guedes, Jéssica de Siqueira, Barreiro, Eliezer J., Lima, Lídia Moreira, Barros-Nepomuceno, Francisco W. A., Pessoa, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144566/
https://www.ncbi.nlm.nih.gov/pubmed/37111767
http://dx.doi.org/10.3390/pharmaceutics15041282

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