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Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats

Sleep problems in astronauts can arise from mission demands and stress and can impact both their health and ability to accomplish mission objectives. In addition to mission-related physical and psychological stressors, the long durations of the proposed Mars missions will expose astronauts to space...

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Autores principales: Sanford, Larry D., Adkins, Austin M., Boden, Alea F., Gotthold, Justin D., Harris, Ryan D., Shuboni-Mulligan, Dorela, Wellman, Laurie L., Britten, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144689/
https://www.ncbi.nlm.nih.gov/pubmed/37109531
http://dx.doi.org/10.3390/life13041002
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author Sanford, Larry D.
Adkins, Austin M.
Boden, Alea F.
Gotthold, Justin D.
Harris, Ryan D.
Shuboni-Mulligan, Dorela
Wellman, Laurie L.
Britten, Richard A.
author_facet Sanford, Larry D.
Adkins, Austin M.
Boden, Alea F.
Gotthold, Justin D.
Harris, Ryan D.
Shuboni-Mulligan, Dorela
Wellman, Laurie L.
Britten, Richard A.
author_sort Sanford, Larry D.
collection PubMed
description Sleep problems in astronauts can arise from mission demands and stress and can impact both their health and ability to accomplish mission objectives. In addition to mission-related physical and psychological stressors, the long durations of the proposed Mars missions will expose astronauts to space radiation (SR), which has a significant impact on the brain and may also alter sleep and physiological functions. Therefore, in this study, we assessed sleep, EEG spectra, activity, and core body temperature (CBT) in rats exposed to SR and compared them to age-matched nonirradiated rats. Male outbred Wistar rats (8–9 months old at the time of the study) received SR (15 cGy GCRsim, n = 15) or served as age- and time-matched controls (CTRL, n = 15) without irradiation. At least 90 days after SR and 3 weeks prior to recording, all rats were implanted with telemetry transmitters for recording EEG, activity, and CBT. Sleep, EEG spectra (delta, 0.5–4 Hz; theta, 4–8 Hz; alpha, 8–12 Hz; sigma, 12–16 Hz; beta, 16–24 Hz), activity, and CBT were examined during light and dark periods and during waking and sleeping states. When compared to the CTRLs, SR produced significant reductions in the amounts of dark period total sleep time, total nonrapid eye movement sleep (NREM), and total rapid eye movement sleep (REM), with significant decreases in light and dark period NREM deltas and dark period REM thetas as well as increases in alpha and sigma in NREM and REM during either light or dark periods. The SR animals showed modest increases in some measures of activity. CBT was significantly reduced during waking and sleeping in the light period. These data demonstrate that SR alone can produce alterations to sleep and temperature control that could have consequences for astronauts and their ability to meet mission demands.
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spelling pubmed-101446892023-04-29 Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats Sanford, Larry D. Adkins, Austin M. Boden, Alea F. Gotthold, Justin D. Harris, Ryan D. Shuboni-Mulligan, Dorela Wellman, Laurie L. Britten, Richard A. Life (Basel) Article Sleep problems in astronauts can arise from mission demands and stress and can impact both their health and ability to accomplish mission objectives. In addition to mission-related physical and psychological stressors, the long durations of the proposed Mars missions will expose astronauts to space radiation (SR), which has a significant impact on the brain and may also alter sleep and physiological functions. Therefore, in this study, we assessed sleep, EEG spectra, activity, and core body temperature (CBT) in rats exposed to SR and compared them to age-matched nonirradiated rats. Male outbred Wistar rats (8–9 months old at the time of the study) received SR (15 cGy GCRsim, n = 15) or served as age- and time-matched controls (CTRL, n = 15) without irradiation. At least 90 days after SR and 3 weeks prior to recording, all rats were implanted with telemetry transmitters for recording EEG, activity, and CBT. Sleep, EEG spectra (delta, 0.5–4 Hz; theta, 4–8 Hz; alpha, 8–12 Hz; sigma, 12–16 Hz; beta, 16–24 Hz), activity, and CBT were examined during light and dark periods and during waking and sleeping states. When compared to the CTRLs, SR produced significant reductions in the amounts of dark period total sleep time, total nonrapid eye movement sleep (NREM), and total rapid eye movement sleep (REM), with significant decreases in light and dark period NREM deltas and dark period REM thetas as well as increases in alpha and sigma in NREM and REM during either light or dark periods. The SR animals showed modest increases in some measures of activity. CBT was significantly reduced during waking and sleeping in the light period. These data demonstrate that SR alone can produce alterations to sleep and temperature control that could have consequences for astronauts and their ability to meet mission demands. MDPI 2023-04-13 /pmc/articles/PMC10144689/ /pubmed/37109531 http://dx.doi.org/10.3390/life13041002 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sanford, Larry D.
Adkins, Austin M.
Boden, Alea F.
Gotthold, Justin D.
Harris, Ryan D.
Shuboni-Mulligan, Dorela
Wellman, Laurie L.
Britten, Richard A.
Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats
title Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats
title_full Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats
title_fullStr Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats
title_full_unstemmed Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats
title_short Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats
title_sort sleep and core body temperature alterations induced by space radiation in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144689/
https://www.ncbi.nlm.nih.gov/pubmed/37109531
http://dx.doi.org/10.3390/life13041002
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