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The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania
Background: Although rare, Fournier’s gangrene is a major urological emergency. We aimed to learn more about the pathogenesis of Fournier’s gangrene and assess the antibiotic resistance patterns in individuals with this disease. Methods: We retrospectively evaluated the patients diagnosed with and t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144816/ https://www.ncbi.nlm.nih.gov/pubmed/37109603 http://dx.doi.org/10.3390/medicina59040643 |
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author | Puia, Dragoş Gheorghincă, Ştefan Pricop, Cătălin |
author_facet | Puia, Dragoş Gheorghincă, Ştefan Pricop, Cătălin |
author_sort | Puia, Dragoş |
collection | PubMed |
description | Background: Although rare, Fournier’s gangrene is a major urological emergency. We aimed to learn more about the pathogenesis of Fournier’s gangrene and assess the antibiotic resistance patterns in individuals with this disease. Methods: We retrospectively evaluated the patients diagnosed with and treated for Fournier’s gangrene in a Neamt county hospital and “CI Parhon” Clinical Hospital in Iasi, Romania between 1 January 2016 and 1 June 2022. Results: We included a total of 40 patients, all males; of these, 12.5% died. In our study, in the patients that died, the adverse prognostic factors were a higher body temperature (38.12 ± 0.68 vs. 38.94 ± 0.85 °C; p = 0.009), an elevated WBC (17.4 ± 5.46 vs. 25.23 ± 7.48; p = 0.003), obesity (14.28% vs. 60%; p = 0.04), and a significantly higher FGSI (4.17 ± 2.80 vs. 9.4 ± 3.2; p = 0.0002) as well as MAR index (0.37 ± 0.29 vs. 0.59 ± 0.24; p = 0.036). These patients were more likely to have liver affections than those in the group who survived, but the difference was not significant. The most frequently identified microorganism in the tissue secretions culture was E. coli (40%), followed by Klebsiella pneumoniae (30%) and Enterococcus (10%). The highest MAR index was encountered in Acinetobacter (1), in a patient that did not survive, followed by Pseudomonas (0.85) and Proteus (0.75). Conclusions: Fournier’s gangrene remains a fatal condition, a highly resistant causative microorganism that is not always correlated with a poor prognosis. |
format | Online Article Text |
id | pubmed-10144816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101448162023-04-29 The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania Puia, Dragoş Gheorghincă, Ştefan Pricop, Cătălin Medicina (Kaunas) Article Background: Although rare, Fournier’s gangrene is a major urological emergency. We aimed to learn more about the pathogenesis of Fournier’s gangrene and assess the antibiotic resistance patterns in individuals with this disease. Methods: We retrospectively evaluated the patients diagnosed with and treated for Fournier’s gangrene in a Neamt county hospital and “CI Parhon” Clinical Hospital in Iasi, Romania between 1 January 2016 and 1 June 2022. Results: We included a total of 40 patients, all males; of these, 12.5% died. In our study, in the patients that died, the adverse prognostic factors were a higher body temperature (38.12 ± 0.68 vs. 38.94 ± 0.85 °C; p = 0.009), an elevated WBC (17.4 ± 5.46 vs. 25.23 ± 7.48; p = 0.003), obesity (14.28% vs. 60%; p = 0.04), and a significantly higher FGSI (4.17 ± 2.80 vs. 9.4 ± 3.2; p = 0.0002) as well as MAR index (0.37 ± 0.29 vs. 0.59 ± 0.24; p = 0.036). These patients were more likely to have liver affections than those in the group who survived, but the difference was not significant. The most frequently identified microorganism in the tissue secretions culture was E. coli (40%), followed by Klebsiella pneumoniae (30%) and Enterococcus (10%). The highest MAR index was encountered in Acinetobacter (1), in a patient that did not survive, followed by Pseudomonas (0.85) and Proteus (0.75). Conclusions: Fournier’s gangrene remains a fatal condition, a highly resistant causative microorganism that is not always correlated with a poor prognosis. MDPI 2023-03-24 /pmc/articles/PMC10144816/ /pubmed/37109603 http://dx.doi.org/10.3390/medicina59040643 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Puia, Dragoş Gheorghincă, Ştefan Pricop, Cătălin The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania |
title | The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania |
title_full | The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania |
title_fullStr | The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania |
title_full_unstemmed | The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania |
title_short | The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier’s Gangrene in a Tertiary Hospital in North Eastern Romania |
title_sort | antimicrobial resistance index and fournier gangrene severity index of patients diagnosed with fournier’s gangrene in a tertiary hospital in north eastern romania |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144816/ https://www.ncbi.nlm.nih.gov/pubmed/37109603 http://dx.doi.org/10.3390/medicina59040643 |
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