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Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis

Background: Outcomes following in-hospital cardiac arrest (IHCA) in patients with COVID-19 have been reported by several small single-institutional studies; however, there are no large studies contrasting COVID-19 IHCA with non-COVID-19 IHCA. The objective of this study was to compare the outcomes f...

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Autores principales: Shrestha, Dhan Bahadur, Sedhai, Yub Raj, Dawadi, Sagun, Dhakal, Bishal, Shtembari, Jurgen, Singh, Karan, Acharya, Roshan, Basnyat, Soney, Waheed, Irfan, Khan, Mohammad Saud, Kazimuddin, Mohammed, Patel, Nimesh K., Kalahasty, Gautham, Bhave, Prashant Dattatraya, Whalen, Patrick, Shantha, Ghanshyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144838/
https://www.ncbi.nlm.nih.gov/pubmed/37109134
http://dx.doi.org/10.3390/jcm12082796
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author Shrestha, Dhan Bahadur
Sedhai, Yub Raj
Dawadi, Sagun
Dhakal, Bishal
Shtembari, Jurgen
Singh, Karan
Acharya, Roshan
Basnyat, Soney
Waheed, Irfan
Khan, Mohammad Saud
Kazimuddin, Mohammed
Patel, Nimesh K.
Kalahasty, Gautham
Bhave, Prashant Dattatraya
Whalen, Patrick
Shantha, Ghanshyam
author_facet Shrestha, Dhan Bahadur
Sedhai, Yub Raj
Dawadi, Sagun
Dhakal, Bishal
Shtembari, Jurgen
Singh, Karan
Acharya, Roshan
Basnyat, Soney
Waheed, Irfan
Khan, Mohammad Saud
Kazimuddin, Mohammed
Patel, Nimesh K.
Kalahasty, Gautham
Bhave, Prashant Dattatraya
Whalen, Patrick
Shantha, Ghanshyam
author_sort Shrestha, Dhan Bahadur
collection PubMed
description Background: Outcomes following in-hospital cardiac arrest (IHCA) in patients with COVID-19 have been reported by several small single-institutional studies; however, there are no large studies contrasting COVID-19 IHCA with non-COVID-19 IHCA. The objective of this study was to compare the outcomes following IHCA between COVID-19 and non-COVID-19 patients. Methods: We searched databases using predefined search terms and appropriate Boolean operators. All the relevant articles published till August 2022 were included in the analyses. The systematic review and meta-analysis were conducted as per Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. An odds ratio with a 95% confidence interval (CI) was used to measure effects. Results: Among 855 studies screened, 6 studies with 27,453 IHCA patients (63.84% male) with COVID-19 and 20,766 (59.7% male) without COVID-19 were included in the analysis. IHCA among patients with COVID-19 has lower odds of achieving return of spontaneous circulation (ROSC) (OR: 0.66, 95% CI: 0.62–0.70). Similarly, patients with COVID-19 have higher odds of 30-day mortality following IHCA (OR: 2.26, 95% CI: 2.08–2.45) and have 45% lower odds of cardiac arrest because of a shockable rhythm (OR: 0.55, 95% CI: 0.50–0.60) (9.59% vs. 16.39%). COVID-19 patients less commonly underwent targeted temperature management (TTM) or coronary angiography; however, they were more commonly intubated and on vasopressor therapy as compared to patients who did not have a COVID-19 infection. Conclusions: This meta-analysis showed that IHCA with COVID-19 has a higher mortality and lower rates of ROSC compared with non-COVID-19 IHCA. COVID-19 is an independent risk factor for poor outcomes in IHCA patients.
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spelling pubmed-101448382023-04-29 Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis Shrestha, Dhan Bahadur Sedhai, Yub Raj Dawadi, Sagun Dhakal, Bishal Shtembari, Jurgen Singh, Karan Acharya, Roshan Basnyat, Soney Waheed, Irfan Khan, Mohammad Saud Kazimuddin, Mohammed Patel, Nimesh K. Kalahasty, Gautham Bhave, Prashant Dattatraya Whalen, Patrick Shantha, Ghanshyam J Clin Med Systematic Review Background: Outcomes following in-hospital cardiac arrest (IHCA) in patients with COVID-19 have been reported by several small single-institutional studies; however, there are no large studies contrasting COVID-19 IHCA with non-COVID-19 IHCA. The objective of this study was to compare the outcomes following IHCA between COVID-19 and non-COVID-19 patients. Methods: We searched databases using predefined search terms and appropriate Boolean operators. All the relevant articles published till August 2022 were included in the analyses. The systematic review and meta-analysis were conducted as per Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. An odds ratio with a 95% confidence interval (CI) was used to measure effects. Results: Among 855 studies screened, 6 studies with 27,453 IHCA patients (63.84% male) with COVID-19 and 20,766 (59.7% male) without COVID-19 were included in the analysis. IHCA among patients with COVID-19 has lower odds of achieving return of spontaneous circulation (ROSC) (OR: 0.66, 95% CI: 0.62–0.70). Similarly, patients with COVID-19 have higher odds of 30-day mortality following IHCA (OR: 2.26, 95% CI: 2.08–2.45) and have 45% lower odds of cardiac arrest because of a shockable rhythm (OR: 0.55, 95% CI: 0.50–0.60) (9.59% vs. 16.39%). COVID-19 patients less commonly underwent targeted temperature management (TTM) or coronary angiography; however, they were more commonly intubated and on vasopressor therapy as compared to patients who did not have a COVID-19 infection. Conclusions: This meta-analysis showed that IHCA with COVID-19 has a higher mortality and lower rates of ROSC compared with non-COVID-19 IHCA. COVID-19 is an independent risk factor for poor outcomes in IHCA patients. MDPI 2023-04-10 /pmc/articles/PMC10144838/ /pubmed/37109134 http://dx.doi.org/10.3390/jcm12082796 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Shrestha, Dhan Bahadur
Sedhai, Yub Raj
Dawadi, Sagun
Dhakal, Bishal
Shtembari, Jurgen
Singh, Karan
Acharya, Roshan
Basnyat, Soney
Waheed, Irfan
Khan, Mohammad Saud
Kazimuddin, Mohammed
Patel, Nimesh K.
Kalahasty, Gautham
Bhave, Prashant Dattatraya
Whalen, Patrick
Shantha, Ghanshyam
Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis
title Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis
title_full Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis
title_fullStr Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis
title_full_unstemmed Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis
title_short Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis
title_sort outcome of in-hospital cardiac arrest among patients with covid-19: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144838/
https://www.ncbi.nlm.nih.gov/pubmed/37109134
http://dx.doi.org/10.3390/jcm12082796
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