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SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany

On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 dogs, originating from 177 German households kn...

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Autores principales: Michelitsch, Anna, Allendorf, Valerie, Conraths, Franz Josef, Gethmann, Jörn, Schulz, Jana, Wernike, Kerstin, Denzin, Nicolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144952/
https://www.ncbi.nlm.nih.gov/pubmed/37112817
http://dx.doi.org/10.3390/v15040837
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author Michelitsch, Anna
Allendorf, Valerie
Conraths, Franz Josef
Gethmann, Jörn
Schulz, Jana
Wernike, Kerstin
Denzin, Nicolai
author_facet Michelitsch, Anna
Allendorf, Valerie
Conraths, Franz Josef
Gethmann, Jörn
Schulz, Jana
Wernike, Kerstin
Denzin, Nicolai
author_sort Michelitsch, Anna
collection PubMed
description On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 dogs, originating from 177 German households known to have been SARS-CoV-2 positive, was determined by enzyme-linked immunosorbent assay (ELISA), and the results were combined with information gathered from a questionnaire that was completed by the owner(s) of the animals. The true seroprevalences of SARS-CoV-2 among cats and dogs were 42.5% (95% CI 33.5–51.9) and 56.8% (95% CI 49.1–64.4), respectively. In a multivariable logistic regression accounting for data clustered in households, for cats, the number of infected humans in the household and an above-average contact intensity turned out to be significant risk factors; contact with humans outside the household was a protective factor. For dogs, on the contrary, contact outside the household was a risk factor, and reduced contact, once the human infection was known, was a significant protective factor. No significant association was found between reported clinical signs in animals and their antibody status, and no spatial clustering of positive test results was identified.
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spelling pubmed-101449522023-04-29 SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany Michelitsch, Anna Allendorf, Valerie Conraths, Franz Josef Gethmann, Jörn Schulz, Jana Wernike, Kerstin Denzin, Nicolai Viruses Article On a global scale, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious threat to the health of the human population. Not only humans can be infected, but also their companion animals. The antibody status of 115 cats and 170 dogs, originating from 177 German households known to have been SARS-CoV-2 positive, was determined by enzyme-linked immunosorbent assay (ELISA), and the results were combined with information gathered from a questionnaire that was completed by the owner(s) of the animals. The true seroprevalences of SARS-CoV-2 among cats and dogs were 42.5% (95% CI 33.5–51.9) and 56.8% (95% CI 49.1–64.4), respectively. In a multivariable logistic regression accounting for data clustered in households, for cats, the number of infected humans in the household and an above-average contact intensity turned out to be significant risk factors; contact with humans outside the household was a protective factor. For dogs, on the contrary, contact outside the household was a risk factor, and reduced contact, once the human infection was known, was a significant protective factor. No significant association was found between reported clinical signs in animals and their antibody status, and no spatial clustering of positive test results was identified. MDPI 2023-03-24 /pmc/articles/PMC10144952/ /pubmed/37112817 http://dx.doi.org/10.3390/v15040837 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michelitsch, Anna
Allendorf, Valerie
Conraths, Franz Josef
Gethmann, Jörn
Schulz, Jana
Wernike, Kerstin
Denzin, Nicolai
SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany
title SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany
title_full SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany
title_fullStr SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany
title_full_unstemmed SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany
title_short SARS-CoV-2 Infection and Clinical Signs in Cats and Dogs from Confirmed Positive Households in Germany
title_sort sars-cov-2 infection and clinical signs in cats and dogs from confirmed positive households in germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144952/
https://www.ncbi.nlm.nih.gov/pubmed/37112817
http://dx.doi.org/10.3390/v15040837
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