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Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension
Apelin, by stimulation of APJ receptors, induces transient blood pressure (BP) reduction and positive inotropic effects. APJ receptors share high homology with the Ang II type 1 receptor; thus, apelin was proposed to play a protective role in cardiovascular disease by antagonizing the actions of Ang...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145143/ https://www.ncbi.nlm.nih.gov/pubmed/37111357 http://dx.doi.org/10.3390/ph16040600 |
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author | Zhang, Qi Shen, Yue Niloy, Sayeman Islam O’Rourke, Stephen T. Sun, Chengwen |
author_facet | Zhang, Qi Shen, Yue Niloy, Sayeman Islam O’Rourke, Stephen T. Sun, Chengwen |
author_sort | Zhang, Qi |
collection | PubMed |
description | Apelin, by stimulation of APJ receptors, induces transient blood pressure (BP) reduction and positive inotropic effects. APJ receptors share high homology with the Ang II type 1 receptor; thus, apelin was proposed to play a protective role in cardiovascular disease by antagonizing the actions of Ang II. In this regard, apelin and apelin-mimetics are currently being studied in clinical trials. However, the chronic effect of apelin in cardiovascular regulation has not been fully investigated. In the current study, blood pressure (BP) and heart rate (HR) were recorded using a telemetry implantation approach in conscious rats, before and during chronic subcutaneous infusion of apelin-13, using osmotic minipumps. At the end of the recording, the cardiac myocyte morphology was examined using H&E staining, and cardiac fibrosis was evaluated by Sirius Red in each group of rats. The results demonstrated that the chronic infusion of apelin-13 did not change either BP or HR. However, under the same condition, the chronic infusion of Ang II induced significant BP elevation, cardiac hypertrophy, and fibrosis. Co-administration of apelin-13 did not significantly alter the Ang II-induced elevation in BP, changes in cardiac morphology, and fibrosis. Taken together, our experiments showed an unexpected result indicating that the chronic administration of apelin-13 did not alter basal BP, nor did it change Ang II-induced hypertension and cardiac hypertrophy. The findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension. |
format | Online Article Text |
id | pubmed-10145143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101451432023-04-29 Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension Zhang, Qi Shen, Yue Niloy, Sayeman Islam O’Rourke, Stephen T. Sun, Chengwen Pharmaceuticals (Basel) Article Apelin, by stimulation of APJ receptors, induces transient blood pressure (BP) reduction and positive inotropic effects. APJ receptors share high homology with the Ang II type 1 receptor; thus, apelin was proposed to play a protective role in cardiovascular disease by antagonizing the actions of Ang II. In this regard, apelin and apelin-mimetics are currently being studied in clinical trials. However, the chronic effect of apelin in cardiovascular regulation has not been fully investigated. In the current study, blood pressure (BP) and heart rate (HR) were recorded using a telemetry implantation approach in conscious rats, before and during chronic subcutaneous infusion of apelin-13, using osmotic minipumps. At the end of the recording, the cardiac myocyte morphology was examined using H&E staining, and cardiac fibrosis was evaluated by Sirius Red in each group of rats. The results demonstrated that the chronic infusion of apelin-13 did not change either BP or HR. However, under the same condition, the chronic infusion of Ang II induced significant BP elevation, cardiac hypertrophy, and fibrosis. Co-administration of apelin-13 did not significantly alter the Ang II-induced elevation in BP, changes in cardiac morphology, and fibrosis. Taken together, our experiments showed an unexpected result indicating that the chronic administration of apelin-13 did not alter basal BP, nor did it change Ang II-induced hypertension and cardiac hypertrophy. The findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension. MDPI 2023-04-17 /pmc/articles/PMC10145143/ /pubmed/37111357 http://dx.doi.org/10.3390/ph16040600 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Qi Shen, Yue Niloy, Sayeman Islam O’Rourke, Stephen T. Sun, Chengwen Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension |
title | Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension |
title_full | Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension |
title_fullStr | Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension |
title_full_unstemmed | Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension |
title_short | Chronic Effects of Apelin on Cardiovascular Regulation and Angiotensin II-Induced Hypertension |
title_sort | chronic effects of apelin on cardiovascular regulation and angiotensin ii-induced hypertension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145143/ https://www.ncbi.nlm.nih.gov/pubmed/37111357 http://dx.doi.org/10.3390/ph16040600 |
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