Cargando…

Renal proximal tubule cells: power and finesse

The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal tubule. Yoon et al. demonstrated the intracellular mechanism by which parathyroid hormone (PTH) increases production of...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuchs, Michaela A.A., Wolf, Myles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145182/
https://www.ncbi.nlm.nih.gov/pubmed/37115697
http://dx.doi.org/10.1172/JCI169607
_version_ 1785034271712346112
author Fuchs, Michaela A.A.
Wolf, Myles
author_facet Fuchs, Michaela A.A.
Wolf, Myles
author_sort Fuchs, Michaela A.A.
collection PubMed
description The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal tubule. Yoon et al. demonstrated the intracellular mechanism by which parathyroid hormone (PTH) increases production of 1,25-vitamin D. Activation of PTH receptor 1/cAMP/PKA signaling inhibited salt-inducible kinase 2 (SIK2) and SIK3, which increased CYB27B1 transcription and 1,25-vitamin D production. Replication of these effects with small-molecule SIK inhibitors suggests possible therapeutic applications for patients with disorders characterized by 1,25-vitamin D deficiency. Zhou et al. discovered that proximal tubule glycolysis acts as a phosphate sensor that regulates fibroblast growth factor 23 production in bone. They described several kidney-specific metabolic modifications that enabled glycolysis to be deployed as a phosphate sensor. The provocative results raise intriguing questions with implications for patients with disorders of phosphate homeostasis, including chronic kidney disease.
format Online
Article
Text
id pubmed-10145182
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Society for Clinical Investigation
record_format MEDLINE/PubMed
spelling pubmed-101451822023-05-01 Renal proximal tubule cells: power and finesse Fuchs, Michaela A.A. Wolf, Myles J Clin Invest Commentary The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal tubule. Yoon et al. demonstrated the intracellular mechanism by which parathyroid hormone (PTH) increases production of 1,25-vitamin D. Activation of PTH receptor 1/cAMP/PKA signaling inhibited salt-inducible kinase 2 (SIK2) and SIK3, which increased CYB27B1 transcription and 1,25-vitamin D production. Replication of these effects with small-molecule SIK inhibitors suggests possible therapeutic applications for patients with disorders characterized by 1,25-vitamin D deficiency. Zhou et al. discovered that proximal tubule glycolysis acts as a phosphate sensor that regulates fibroblast growth factor 23 production in bone. They described several kidney-specific metabolic modifications that enabled glycolysis to be deployed as a phosphate sensor. The provocative results raise intriguing questions with implications for patients with disorders of phosphate homeostasis, including chronic kidney disease. American Society for Clinical Investigation 2023-05-01 /pmc/articles/PMC10145182/ /pubmed/37115697 http://dx.doi.org/10.1172/JCI169607 Text en © 2023 Fuchs et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Fuchs, Michaela A.A.
Wolf, Myles
Renal proximal tubule cells: power and finesse
title Renal proximal tubule cells: power and finesse
title_full Renal proximal tubule cells: power and finesse
title_fullStr Renal proximal tubule cells: power and finesse
title_full_unstemmed Renal proximal tubule cells: power and finesse
title_short Renal proximal tubule cells: power and finesse
title_sort renal proximal tubule cells: power and finesse
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145182/
https://www.ncbi.nlm.nih.gov/pubmed/37115697
http://dx.doi.org/10.1172/JCI169607
work_keys_str_mv AT fuchsmichaelaaa renalproximaltubulecellspowerandfinesse
AT wolfmyles renalproximaltubulecellspowerandfinesse