Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source

Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a mosaic RASopathy characterized by the association of dysplastic skeletal lesions, congenital skin nevi of epidermal and/or melanocytic origin, and FGF23-mediated hypophosphatemia. The primary physiological source of circulating FGF23 is bone c...

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Detalles Bibliográficos
Autores principales: Ovejero, Diana, Michel, Zachary, Cataisson, Christophe, Saikali, Amanda, Galisteo, Rebeca, Yuspa, Stuart H., Collins, Michael T., de Castro, Luis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145192/
https://www.ncbi.nlm.nih.gov/pubmed/36943390
http://dx.doi.org/10.1172/JCI159330

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