Cargando…

Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery

The severe course of COVID-19 leads to the long-terming pulmonary diseases, such as bacterial pneumonia and post-COVID-19 pulmonary fibrosis. Thus, the essential task of biomedicine is a design of new effective drug formulations, including those for inhalation administration. In this work, we propos...

Descripción completa

Detalles Bibliográficos
Autores principales: Le-Deygen, Irina, Safronova, Anastasia, Mamaeva, Polina, Khristidis, Yana, Kolmogorov, Ilya, Skuredina, Anna, Timashev, Peter, Kudryashova, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145208/
https://www.ncbi.nlm.nih.gov/pubmed/37111586
http://dx.doi.org/10.3390/pharmaceutics15041101
_version_ 1785034277932498944
author Le-Deygen, Irina
Safronova, Anastasia
Mamaeva, Polina
Khristidis, Yana
Kolmogorov, Ilya
Skuredina, Anna
Timashev, Peter
Kudryashova, Elena
author_facet Le-Deygen, Irina
Safronova, Anastasia
Mamaeva, Polina
Khristidis, Yana
Kolmogorov, Ilya
Skuredina, Anna
Timashev, Peter
Kudryashova, Elena
author_sort Le-Deygen, Irina
collection PubMed
description The severe course of COVID-19 leads to the long-terming pulmonary diseases, such as bacterial pneumonia and post-COVID-19 pulmonary fibrosis. Thus, the essential task of biomedicine is a design of new effective drug formulations, including those for inhalation administration. In this work, we propose an approach to the creation of lipid–polymer delivery systems for fluoroquinolones and pirfenidone based on liposomes of various compositions decorated with mucoadhesive mannosylated chitosan. A generalizing study on the physicochemical patterns of the interactions of drugs with bilayers of various compositions was carried out, and the main binding sites were identified. The role of the polymer shell in the stabilization of vesicles and the delayed release of the contents has been demonstrated. For the liquid–polymer formulation of moxifloxacin, a prolonged accumulation of the drug in lung tissues was found after a single endotracheal administration to mice, significantly exceeding the control intravenous and endotracheal administration of the drug.
format Online
Article
Text
id pubmed-10145208
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101452082023-04-29 Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery Le-Deygen, Irina Safronova, Anastasia Mamaeva, Polina Khristidis, Yana Kolmogorov, Ilya Skuredina, Anna Timashev, Peter Kudryashova, Elena Pharmaceutics Article The severe course of COVID-19 leads to the long-terming pulmonary diseases, such as bacterial pneumonia and post-COVID-19 pulmonary fibrosis. Thus, the essential task of biomedicine is a design of new effective drug formulations, including those for inhalation administration. In this work, we propose an approach to the creation of lipid–polymer delivery systems for fluoroquinolones and pirfenidone based on liposomes of various compositions decorated with mucoadhesive mannosylated chitosan. A generalizing study on the physicochemical patterns of the interactions of drugs with bilayers of various compositions was carried out, and the main binding sites were identified. The role of the polymer shell in the stabilization of vesicles and the delayed release of the contents has been demonstrated. For the liquid–polymer formulation of moxifloxacin, a prolonged accumulation of the drug in lung tissues was found after a single endotracheal administration to mice, significantly exceeding the control intravenous and endotracheal administration of the drug. MDPI 2023-03-29 /pmc/articles/PMC10145208/ /pubmed/37111586 http://dx.doi.org/10.3390/pharmaceutics15041101 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Le-Deygen, Irina
Safronova, Anastasia
Mamaeva, Polina
Khristidis, Yana
Kolmogorov, Ilya
Skuredina, Anna
Timashev, Peter
Kudryashova, Elena
Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery
title Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery
title_full Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery
title_fullStr Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery
title_full_unstemmed Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery
title_short Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery
title_sort liposomal forms of fluoroquinolones and antifibrotics decorated with mannosylated chitosan for inhalation drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145208/
https://www.ncbi.nlm.nih.gov/pubmed/37111586
http://dx.doi.org/10.3390/pharmaceutics15041101
work_keys_str_mv AT ledeygenirina liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT safronovaanastasia liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT mamaevapolina liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT khristidisyana liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT kolmogorovilya liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT skuredinaanna liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT timashevpeter liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery
AT kudryashovaelena liposomalformsoffluoroquinolonesandantifibroticsdecoratedwithmannosylatedchitosanforinhalationdrugdelivery