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Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles

Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite...

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Autores principales: Quarta, Eride, Chiappi, Michele, Adamiano, Alessio, Tampieri, Anna, Wang, Weijie, Tetley, Teresa D., Buttini, Francesca, Sonvico, Fabio, Catalucci, Daniele, Colombo, Paolo, Iafisco, Michele, Degli Esposti, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145219/
https://www.ncbi.nlm.nih.gov/pubmed/37103279
http://dx.doi.org/10.3390/jfb14040189
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author Quarta, Eride
Chiappi, Michele
Adamiano, Alessio
Tampieri, Anna
Wang, Weijie
Tetley, Teresa D.
Buttini, Francesca
Sonvico, Fabio
Catalucci, Daniele
Colombo, Paolo
Iafisco, Michele
Degli Esposti, Lorenzo
author_facet Quarta, Eride
Chiappi, Michele
Adamiano, Alessio
Tampieri, Anna
Wang, Weijie
Tetley, Teresa D.
Buttini, Francesca
Sonvico, Fabio
Catalucci, Daniele
Colombo, Paolo
Iafisco, Michele
Degli Esposti, Lorenzo
author_sort Quarta, Eride
collection PubMed
description Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite) nanoparticles (FeCaP NPs) which were previously proved to be excellent materials for magnetic resonance imaging, drug delivery and hyperthermia-related applications. We have established that FeCaP NPs are not cytotoxic towards human lung alveolar epithelial type 1 (AT1) cells even at high doses, thus proving their safety for inhalation administration. Then, D-mannitol spray-dried microparticles embedding FeCaP NPs have been formulated, obtaining respirable dry powders. These microparticles were designed to achieve the best aerodynamic particle size distribution which is a critical condition for successful inhalation and deposition. The nanoparticle-in-microparticle approach resulted in the protection of FeCaP NPs, allowing their release upon microparticle dissolution, with dimensions and surface charge close to the original values. This work demonstrates the use of spray drying to provide an inhalable dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications.
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spelling pubmed-101452192023-04-29 Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles Quarta, Eride Chiappi, Michele Adamiano, Alessio Tampieri, Anna Wang, Weijie Tetley, Teresa D. Buttini, Francesca Sonvico, Fabio Catalucci, Daniele Colombo, Paolo Iafisco, Michele Degli Esposti, Lorenzo J Funct Biomater Article Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite) nanoparticles (FeCaP NPs) which were previously proved to be excellent materials for magnetic resonance imaging, drug delivery and hyperthermia-related applications. We have established that FeCaP NPs are not cytotoxic towards human lung alveolar epithelial type 1 (AT1) cells even at high doses, thus proving their safety for inhalation administration. Then, D-mannitol spray-dried microparticles embedding FeCaP NPs have been formulated, obtaining respirable dry powders. These microparticles were designed to achieve the best aerodynamic particle size distribution which is a critical condition for successful inhalation and deposition. The nanoparticle-in-microparticle approach resulted in the protection of FeCaP NPs, allowing their release upon microparticle dissolution, with dimensions and surface charge close to the original values. This work demonstrates the use of spray drying to provide an inhalable dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications. MDPI 2023-03-28 /pmc/articles/PMC10145219/ /pubmed/37103279 http://dx.doi.org/10.3390/jfb14040189 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Quarta, Eride
Chiappi, Michele
Adamiano, Alessio
Tampieri, Anna
Wang, Weijie
Tetley, Teresa D.
Buttini, Francesca
Sonvico, Fabio
Catalucci, Daniele
Colombo, Paolo
Iafisco, Michele
Degli Esposti, Lorenzo
Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
title Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
title_full Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
title_fullStr Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
title_full_unstemmed Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
title_short Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
title_sort inhalable microparticles embedding biocompatible magnetic iron-doped hydroxyapatite nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145219/
https://www.ncbi.nlm.nih.gov/pubmed/37103279
http://dx.doi.org/10.3390/jfb14040189
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