Caveats of Using Overexpression Approaches to Screen Cellular Host IFITM Proteins for Antiviral Activity

Ectopic protein overexpression in immortalised cell lines is a commonly used method to screen host factors for their antiviral activity against different viruses. However, the question remains as to what extent such artificial protein overexpression recapitulates endogenous protein function. Previou...

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Detalles Bibliográficos
Autores principales: Meischel, Tina, Fritzlar, Svenja, Villalón-Letelier, Fernando, Smith, Jeffrey M., Brooks, Andrew G., Reading, Patrick C., Londrigan, Sarah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145288/
https://www.ncbi.nlm.nih.gov/pubmed/37111405
http://dx.doi.org/10.3390/pathogens12040519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145288/
https://www.ncbi.nlm.nih.gov/pubmed/37111405
http://dx.doi.org/10.3390/pathogens12040519

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