High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma

Chordomas account for approximately 1–4% of all malignant bone tumors and 20% of primary tumors of the spinal column. It is a rare disease, with an incidence estimated to be approximately 1 per 1,000,000 people. The underlying causative mechanism of chordoma is unknown, which makes it challenging to...

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Detalles Bibliográficos
Autores principales: Ajay, Amrendra K., Chu, Philip, Patel, Poojan, Deban, Christa, Roychowdhury, Chitran, Heda, Radhika, Halawi, Ahmad, Saad, Anis, Younis, Nour, Zhang, Hao, Jiang, Xiuju, Nasr, Mahmoud, Hsiao, Li-Li, Lin, Gang, Azzi, Jamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145398/
https://www.ncbi.nlm.nih.gov/pubmed/37111759
http://dx.doi.org/10.3390/pharmaceutics15041274

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