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Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study

Background: The role of gastrointestinal microbiome in health and disease is increasingly appreciated. A significant amount of evidence clearly points to a dysbiosis manifest in inflammatory bowel disease (IBD) when compared to healthy controls. Less understood is the microbiome profile in autoimmun...

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Autores principales: Lopez, Robert N., Leach, Steven T., Bowcock, Nerissa, Coker, Elise, Shapiro, Amanda J., Day, Andrew S., Lemberg, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145405/
https://www.ncbi.nlm.nih.gov/pubmed/37111471
http://dx.doi.org/10.3390/pathogens12040585
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author Lopez, Robert N.
Leach, Steven T.
Bowcock, Nerissa
Coker, Elise
Shapiro, Amanda J.
Day, Andrew S.
Lemberg, Daniel A.
author_facet Lopez, Robert N.
Leach, Steven T.
Bowcock, Nerissa
Coker, Elise
Shapiro, Amanda J.
Day, Andrew S.
Lemberg, Daniel A.
author_sort Lopez, Robert N.
collection PubMed
description Background: The role of gastrointestinal microbiome in health and disease is increasingly appreciated. A significant amount of evidence clearly points to a dysbiosis manifest in inflammatory bowel disease (IBD) when compared to healthy controls. Less understood is the microbiome profile in autoimmune liver disease (AILD). Both adult and paediatric data indicate a distinct microbial signature in patients with IBD and co-existent primary sclerosing cholangitis (PSC), which is unique and different compared to the microbial signature that exists in patients with IBD alone. However, there is limited information on the microbiome make-up of patients with parenchymal liver disease, with or without IBD. Methods: The present study sought to compare the microbiome of children with IBD, to those with IBD-AILD, those with AILD alone and those of healthy controls. Results: Results from this work indicate that children with AILD have a microbiome profile that mirrors healthy controls. Conclusion: Those with IBD-AILD and IBD have similar microbiome profiles which are distinct from AILD alone and healthy controls. This suggests that the dysbiosis in these groups is primarily due to IBD rather than AILD.
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spelling pubmed-101454052023-04-29 Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study Lopez, Robert N. Leach, Steven T. Bowcock, Nerissa Coker, Elise Shapiro, Amanda J. Day, Andrew S. Lemberg, Daniel A. Pathogens Article Background: The role of gastrointestinal microbiome in health and disease is increasingly appreciated. A significant amount of evidence clearly points to a dysbiosis manifest in inflammatory bowel disease (IBD) when compared to healthy controls. Less understood is the microbiome profile in autoimmune liver disease (AILD). Both adult and paediatric data indicate a distinct microbial signature in patients with IBD and co-existent primary sclerosing cholangitis (PSC), which is unique and different compared to the microbial signature that exists in patients with IBD alone. However, there is limited information on the microbiome make-up of patients with parenchymal liver disease, with or without IBD. Methods: The present study sought to compare the microbiome of children with IBD, to those with IBD-AILD, those with AILD alone and those of healthy controls. Results: Results from this work indicate that children with AILD have a microbiome profile that mirrors healthy controls. Conclusion: Those with IBD-AILD and IBD have similar microbiome profiles which are distinct from AILD alone and healthy controls. This suggests that the dysbiosis in these groups is primarily due to IBD rather than AILD. MDPI 2023-04-12 /pmc/articles/PMC10145405/ /pubmed/37111471 http://dx.doi.org/10.3390/pathogens12040585 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lopez, Robert N.
Leach, Steven T.
Bowcock, Nerissa
Coker, Elise
Shapiro, Amanda J.
Day, Andrew S.
Lemberg, Daniel A.
Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study
title Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study
title_full Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study
title_fullStr Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study
title_full_unstemmed Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study
title_short Differences in Gut Microbiome Profile between Healthy Children and Children with Inflammatory Bowel Disease and/or Autoimmune Liver Disease: A Case-Control Study
title_sort differences in gut microbiome profile between healthy children and children with inflammatory bowel disease and/or autoimmune liver disease: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145405/
https://www.ncbi.nlm.nih.gov/pubmed/37111471
http://dx.doi.org/10.3390/pathogens12040585
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