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Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes
Four new dammarane triterpenoid saponins cypaliurusides Z(1)–Z(4) (1–4) and eight known analogs (5–12) were isolated from the leaves of Cyclocarya paliurus. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study de...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145478/ https://www.ncbi.nlm.nih.gov/pubmed/37110527 http://dx.doi.org/10.3390/molecules28083294 |
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author | Liang, Xiaoqin Deng, Shengping Huang, Yan Pan, Liwei Chang, Yanling Hou, Ping Ren, Chenyang Xu, Weifeng Yang, Ruiyun Li, Kanyuan Li, Jun He, Ruijie |
author_facet | Liang, Xiaoqin Deng, Shengping Huang, Yan Pan, Liwei Chang, Yanling Hou, Ping Ren, Chenyang Xu, Weifeng Yang, Ruiyun Li, Kanyuan Li, Jun He, Ruijie |
author_sort | Liang, Xiaoqin |
collection | PubMed |
description | Four new dammarane triterpenoid saponins cypaliurusides Z(1)–Z(4) (1–4) and eight known analogs (5–12) were isolated from the leaves of Cyclocarya paliurus. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit. The effects of the isolates on insulin-stimulated glucose uptake in 3T3-L1 adipocytes were evaluated and three dammarane triterpenoid saponins (6, 7 and 10) were found to enhance insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Furthermore, compounds 6, 7, and 10 exhibited potent abilities to promote insulin-stimulated glucose uptake in 3T3-L1 adipocytes in a dose-dependent manner. Thus, the abundant dammarane triterpenoid saponins from C. paliurus leaves exhibited stimulatory effects on glucose uptake with application potential as a antidiabetic treatment. |
format | Online Article Text |
id | pubmed-10145478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101454782023-04-29 Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes Liang, Xiaoqin Deng, Shengping Huang, Yan Pan, Liwei Chang, Yanling Hou, Ping Ren, Chenyang Xu, Weifeng Yang, Ruiyun Li, Kanyuan Li, Jun He, Ruijie Molecules Article Four new dammarane triterpenoid saponins cypaliurusides Z(1)–Z(4) (1–4) and eight known analogs (5–12) were isolated from the leaves of Cyclocarya paliurus. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit. The effects of the isolates on insulin-stimulated glucose uptake in 3T3-L1 adipocytes were evaluated and three dammarane triterpenoid saponins (6, 7 and 10) were found to enhance insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Furthermore, compounds 6, 7, and 10 exhibited potent abilities to promote insulin-stimulated glucose uptake in 3T3-L1 adipocytes in a dose-dependent manner. Thus, the abundant dammarane triterpenoid saponins from C. paliurus leaves exhibited stimulatory effects on glucose uptake with application potential as a antidiabetic treatment. MDPI 2023-04-07 /pmc/articles/PMC10145478/ /pubmed/37110527 http://dx.doi.org/10.3390/molecules28083294 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liang, Xiaoqin Deng, Shengping Huang, Yan Pan, Liwei Chang, Yanling Hou, Ping Ren, Chenyang Xu, Weifeng Yang, Ruiyun Li, Kanyuan Li, Jun He, Ruijie Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes |
title | Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes |
title_full | Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes |
title_fullStr | Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes |
title_full_unstemmed | Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes |
title_short | Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes |
title_sort | triterpenoids from the leaves of cyclocarya paliurus and their glucose uptake activity in 3t3-l1 adipocytes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145478/ https://www.ncbi.nlm.nih.gov/pubmed/37110527 http://dx.doi.org/10.3390/molecules28083294 |
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