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Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children
Neuroborreliosis is a form of Lyme Borreliosis (LB) that affects various structures of the central and peripheral nervous system. Although most cases of LB can be cured with a course of antibiotics, some children can present prolonged symptoms, which may constitute post-treatment Lyme disease syndro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145507/ https://www.ncbi.nlm.nih.gov/pubmed/37109429 http://dx.doi.org/10.3390/life13040900 |
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author | Myszkowska-Torz, Agnieszka Frydrychowicz, Magdalena Tomaszewski, Mateusz Figlerowicz, Magdalena Mania, Anna Mazur-Melewska, Katarzyna |
author_facet | Myszkowska-Torz, Agnieszka Frydrychowicz, Magdalena Tomaszewski, Mateusz Figlerowicz, Magdalena Mania, Anna Mazur-Melewska, Katarzyna |
author_sort | Myszkowska-Torz, Agnieszka |
collection | PubMed |
description | Neuroborreliosis is a form of Lyme Borreliosis (LB) that affects various structures of the central and peripheral nervous system. Although most cases of LB can be cured with a course of antibiotics, some children can present prolonged symptoms, which may constitute post-treatment Lyme disease syndrome (PTLDS). The aim of our analysis was the long-term observation of children with NB and the determination of their risk of PTLDS. The clinical observation was supplemented by a laboratory study based on the assessment of the dynamics of anti-VlsE (variable major protein-like sequence, expressed) IgG antibodies in children with NB after antibiotic therapy. The prospective survey based on 40 children presented 1–2 forms of NB. The control group consisted of 36 patients with analogical symptoms for whom LB was excluded. Our long-term observation showed a low risk of developing long-term complications in children who received antibiotic therapy in accordance with the recommendations. The concentration of anti-VlsE IgG demonstrates a statistical significance for differences between the control and the study groups for each measurement period. Higher values of anti-VlsE IgG were observed in the study group, and the concentration decreased from the first measurement period to the next. The article emphasizes the importance of the long-term follow-up of children with neuroborreliosis. |
format | Online Article Text |
id | pubmed-10145507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101455072023-04-29 Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children Myszkowska-Torz, Agnieszka Frydrychowicz, Magdalena Tomaszewski, Mateusz Figlerowicz, Magdalena Mania, Anna Mazur-Melewska, Katarzyna Life (Basel) Article Neuroborreliosis is a form of Lyme Borreliosis (LB) that affects various structures of the central and peripheral nervous system. Although most cases of LB can be cured with a course of antibiotics, some children can present prolonged symptoms, which may constitute post-treatment Lyme disease syndrome (PTLDS). The aim of our analysis was the long-term observation of children with NB and the determination of their risk of PTLDS. The clinical observation was supplemented by a laboratory study based on the assessment of the dynamics of anti-VlsE (variable major protein-like sequence, expressed) IgG antibodies in children with NB after antibiotic therapy. The prospective survey based on 40 children presented 1–2 forms of NB. The control group consisted of 36 patients with analogical symptoms for whom LB was excluded. Our long-term observation showed a low risk of developing long-term complications in children who received antibiotic therapy in accordance with the recommendations. The concentration of anti-VlsE IgG demonstrates a statistical significance for differences between the control and the study groups for each measurement period. Higher values of anti-VlsE IgG were observed in the study group, and the concentration decreased from the first measurement period to the next. The article emphasizes the importance of the long-term follow-up of children with neuroborreliosis. MDPI 2023-03-28 /pmc/articles/PMC10145507/ /pubmed/37109429 http://dx.doi.org/10.3390/life13040900 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Myszkowska-Torz, Agnieszka Frydrychowicz, Magdalena Tomaszewski, Mateusz Figlerowicz, Magdalena Mania, Anna Mazur-Melewska, Katarzyna Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children |
title | Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children |
title_full | Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children |
title_fullStr | Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children |
title_full_unstemmed | Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children |
title_short | Neuroborreliosis and Post-Treatment Lyme Disease Syndrome: Focus on Children |
title_sort | neuroborreliosis and post-treatment lyme disease syndrome: focus on children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145507/ https://www.ncbi.nlm.nih.gov/pubmed/37109429 http://dx.doi.org/10.3390/life13040900 |
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