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Multidrug Resistance in Critically Ill Patients: An Unresolved Issue

Sepsis and septic shock are common in critically ill patients and, as recommended by the Surviving Sepsis Campaign (SSC), early empiric antimicrobial therapy, specifically within the first hour, is crucial for the successful management of these conditions. To be effective, the antimicrobial therapy...

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Detalles Bibliográficos
Autor principal: Spadaro, Savino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145547/
https://www.ncbi.nlm.nih.gov/pubmed/37110369
http://dx.doi.org/10.3390/microorganisms11040946
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author Spadaro, Savino
author_facet Spadaro, Savino
author_sort Spadaro, Savino
collection PubMed
description Sepsis and septic shock are common in critically ill patients and, as recommended by the Surviving Sepsis Campaign (SSC), early empiric antimicrobial therapy, specifically within the first hour, is crucial for the successful management of these conditions. To be effective, the antimicrobial therapy must also be appropriately administered: the drugs should cover the most probable pathogens and achieve effective concentrations at the site of infection. However, pharmacokinetics are frequently altered in critically ill patients and continuously change since the clinical conditions of these patients quickly and markedly change over time, either improving or deteriorating. Accordingly, optimizing antimicrobial drug dosing is fundamental in intensive care units (ICUs). This Special Issue of Microorganisms examines the epidemiology, diagnostic innovations, and strategies applied in the context of infections in critically ill patients with MDR infections.
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spelling pubmed-101455472023-04-29 Multidrug Resistance in Critically Ill Patients: An Unresolved Issue Spadaro, Savino Microorganisms Editorial Sepsis and septic shock are common in critically ill patients and, as recommended by the Surviving Sepsis Campaign (SSC), early empiric antimicrobial therapy, specifically within the first hour, is crucial for the successful management of these conditions. To be effective, the antimicrobial therapy must also be appropriately administered: the drugs should cover the most probable pathogens and achieve effective concentrations at the site of infection. However, pharmacokinetics are frequently altered in critically ill patients and continuously change since the clinical conditions of these patients quickly and markedly change over time, either improving or deteriorating. Accordingly, optimizing antimicrobial drug dosing is fundamental in intensive care units (ICUs). This Special Issue of Microorganisms examines the epidemiology, diagnostic innovations, and strategies applied in the context of infections in critically ill patients with MDR infections. MDPI 2023-04-04 /pmc/articles/PMC10145547/ /pubmed/37110369 http://dx.doi.org/10.3390/microorganisms11040946 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Spadaro, Savino
Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
title Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
title_full Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
title_fullStr Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
title_full_unstemmed Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
title_short Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
title_sort multidrug resistance in critically ill patients: an unresolved issue
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145547/
https://www.ncbi.nlm.nih.gov/pubmed/37110369
http://dx.doi.org/10.3390/microorganisms11040946
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