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Multidrug Resistance in Critically Ill Patients: An Unresolved Issue
Sepsis and septic shock are common in critically ill patients and, as recommended by the Surviving Sepsis Campaign (SSC), early empiric antimicrobial therapy, specifically within the first hour, is crucial for the successful management of these conditions. To be effective, the antimicrobial therapy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145547/ https://www.ncbi.nlm.nih.gov/pubmed/37110369 http://dx.doi.org/10.3390/microorganisms11040946 |
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author | Spadaro, Savino |
author_facet | Spadaro, Savino |
author_sort | Spadaro, Savino |
collection | PubMed |
description | Sepsis and septic shock are common in critically ill patients and, as recommended by the Surviving Sepsis Campaign (SSC), early empiric antimicrobial therapy, specifically within the first hour, is crucial for the successful management of these conditions. To be effective, the antimicrobial therapy must also be appropriately administered: the drugs should cover the most probable pathogens and achieve effective concentrations at the site of infection. However, pharmacokinetics are frequently altered in critically ill patients and continuously change since the clinical conditions of these patients quickly and markedly change over time, either improving or deteriorating. Accordingly, optimizing antimicrobial drug dosing is fundamental in intensive care units (ICUs). This Special Issue of Microorganisms examines the epidemiology, diagnostic innovations, and strategies applied in the context of infections in critically ill patients with MDR infections. |
format | Online Article Text |
id | pubmed-10145547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101455472023-04-29 Multidrug Resistance in Critically Ill Patients: An Unresolved Issue Spadaro, Savino Microorganisms Editorial Sepsis and septic shock are common in critically ill patients and, as recommended by the Surviving Sepsis Campaign (SSC), early empiric antimicrobial therapy, specifically within the first hour, is crucial for the successful management of these conditions. To be effective, the antimicrobial therapy must also be appropriately administered: the drugs should cover the most probable pathogens and achieve effective concentrations at the site of infection. However, pharmacokinetics are frequently altered in critically ill patients and continuously change since the clinical conditions of these patients quickly and markedly change over time, either improving or deteriorating. Accordingly, optimizing antimicrobial drug dosing is fundamental in intensive care units (ICUs). This Special Issue of Microorganisms examines the epidemiology, diagnostic innovations, and strategies applied in the context of infections in critically ill patients with MDR infections. MDPI 2023-04-04 /pmc/articles/PMC10145547/ /pubmed/37110369 http://dx.doi.org/10.3390/microorganisms11040946 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Spadaro, Savino Multidrug Resistance in Critically Ill Patients: An Unresolved Issue |
title | Multidrug Resistance in Critically Ill Patients: An Unresolved Issue |
title_full | Multidrug Resistance in Critically Ill Patients: An Unresolved Issue |
title_fullStr | Multidrug Resistance in Critically Ill Patients: An Unresolved Issue |
title_full_unstemmed | Multidrug Resistance in Critically Ill Patients: An Unresolved Issue |
title_short | Multidrug Resistance in Critically Ill Patients: An Unresolved Issue |
title_sort | multidrug resistance in critically ill patients: an unresolved issue |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145547/ https://www.ncbi.nlm.nih.gov/pubmed/37110369 http://dx.doi.org/10.3390/microorganisms11040946 |
work_keys_str_mv | AT spadarosavino multidrugresistanceincriticallyillpatientsanunresolvedissue |