Cargando…

Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery

The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS). Because of this barrier there is still a huge unmet need for the treatment of these diseases, despite years of research efforts across the pharmac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meyer, Axel H., Feldsien, Thomas M., Mezler, Mario, Untucht, Christopher, Venugopalan, Ramakrishna, Lefebvre, Didier R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145602/ https://www.ncbi.nlm.nih.gov/pubmed/37111587 http://dx.doi.org/10.3390/pharmaceutics15041100

Ejemplares similares

Nanogels as novel drug nanocarriers for CNS drug delivery
por: Manimaran, V., et al.
Publicado: (2023)

Trafficking of JC virus-like particles across the blood–brain barrier
por: Ye, Dong, et al.
Publicado: (2021)

Perispinal Delivery of CNS Drugs
por: Tobinick, Edward Lewis
Publicado: (2016)

Exosomes as CNS Drug Delivery Tools and Their Applications
por: Sun, Ke, et al.
Publicado: (2022)

Nanotherapeutics in Neuropathologies: Obstacles, Challenges and Recent Advancements in CNS Targeted Drug Delivery Systems
por: Patel, Vimal, et al.
Publicado: (2021)

Nanotechnology-based drug delivery for the treatment of CNS disorders
por: Mittal, Khushi R., et al.
Publicado: (2022)

Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets
por: Kharkar, Prashant S.
Publicado: (2014)

The Promise and Perils of CNS Drug Delivery: A Video Debate
por: Gendelman, Howard E., et al.
Publicado: (2008)

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier
por: Upadhyay, Ravi Kant
Publicado: (2014)

Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia
por: Rajendran, Rajalakshmi, et al.
Publicado: (2022)

Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery
por: Maher, Rebecca, et al.
Publicado: (2023)

Nanogels as Novel Nanocarrier Systems for Efficient Delivery of CNS Therapeutics
por: Zhang, Yunhan, et al.
Publicado: (2022)

Nanocarriers for Delivery of Oligonucleotides to the CNS
por: Male, David, et al.
Publicado: (2022)

Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS
por: Silva, Gabriel A
Publicado: (2008)

Current approaches to enhance CNS delivery of drugs across the brain barriers
por: Lu, Cui-Tao, et al.
Publicado: (2014)

Drug Delivery Technology to the CNS in the Treatment of Brain Tumors: The Sherbrooke Experience
por: Fortin, David
Publicado: (2019)

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis
por: Abdul Razzak, Rana, et al.
Publicado: (2019)

Modeling CNS Development and Disease
por: Weick, Jason P., et al.
Publicado: (2016)

Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts
por: Porath, Kendra A, et al.
Publicado: (2022)

Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development
por: McCluskey, Stuart P., et al.
Publicado: (2019)

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier
por: Strazielle, Nathalie, et al.
Publicado: (2016)

Lomustine’s nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment
por: Alaayedi, Maryam H., et al.
Publicado: (2023)

Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery
por: Chen, Ganghui, et al.
Publicado: (2023)

The potential of (1)H-MRS in CNS drug development
por: Egerton, Alice
Publicado: (2019)

Development of Novel Zn(2+) Loaded Nanoparticles Designed for Cell-Type Targeted Drug Release in CNS Neurons: In Vitro Evidences
por: Grabrucker, Andreas M., et al.
Publicado: (2011)

Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study
por: Saleh, Mohammed A. A., et al.
Publicado: (2021)

Filling the gap in CNS drug development: evaluation of the role of drug repurposing
por: Caban, A., et al.
Publicado: (2017)

Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB
por: Kimura, Seigo, et al.
Publicado: (2020)

Antibody-based Validation of CNS Ion Channel Drug Targets
por: Rhodes, Kenneth J., et al.
Publicado: (2008)

L-type calcium channels as drug targets in CNS disorders
por: Ortner, Nadine J, et al.
Publicado: (2015)

Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages
por: Gong, Yuqing, et al.
Publicado: (2020)

Challenging New Targets for CNS–HIV Infection
por: Ganau, Mario, et al.
Publicado: (2012)

Editorial: Neuro-Immune Connections to Enable Repair in CNS Disorders
por: Vanmierlo, Tim, et al.
Publicado: (2020)

The Rostral Migratory Stream Plays a Key Role in Intranasal Delivery of Drugs into the CNS
por: Scranton, Robert A., et al.
Publicado: (2011)

Experimental Models of In Vitro Blood–Brain Barrier for CNS Drug Delivery: An Evolutionary Perspective
por: Chaulagain, Bivek, et al.
Publicado: (2023)

BSLD-01 DYNAMIC CONTROL OF CSF FOR PERSONALIZED CNS DRUG DELIVERY FOR LEPTOMINGEAL DISEASE
por: Kumthekar, Priya, et al.
Publicado: (2023)

Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting
por: Palmer, Brian C., et al.
Publicado: (2016)

Novel insights into the origin and development of CNS macrophage subsets
por: Masuda, Takahiro, et al.
Publicado: (2022)

Efficient CPP-mediated Cre protein delivery to developing and adult CNS tissues
por: Gitton, Yorick, et al.
Publicado: (2009)

Challenges in Permeability Assessment for Oral Drug Product Development
por: Koziolek, Mirko, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_demqt62a883h6k0pemmfej05sn