Increase in Registered Acute Kidney Injuries in German Hospitals

Background: Currently, the development of the incidence of acute kidney injury (AKI) and the influence of age and gender on the condition in Germany is unclear. Materials and Methods: Data were extracted from the national database of Federal Health Reporting. It was then normalized for demographic changes. Poisson regression was performed on 933,684 cases to quantify the correlation between age, years, and AKI incidence. Analysis of variance was performed on the same collection to evaluate gender disparities in different age groups. Results: In absolute numbers, registered AKI increased almost sevenfold from 11,964 to 77,719 between 2000 and 2019. After adjusting for demographic changes, the most AKI - 6300.5 per million person-years - occur in the elderly (>79 years old). Males have a higher risk for the development of an AKI. The male and female AKI incidence ratio varies significantly between different age groups, and it is the lowest in people <20 and >79 years old. Conclusions: The registered incidence of AKI has risen substantially in the first 20 years of the millennium. The increase can partly be attributed to an increased diagnostic sensitivity provided by changes in the classification of AKI. It could also be shown that men suffer from AKI more often than women, particularly in the younger age groups.