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Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 20...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145689/ https://www.ncbi.nlm.nih.gov/pubmed/37109171 http://dx.doi.org/10.3390/jcm12082829 |
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author | Spadaccini, Marco Conti Bellocchi, Maria Cristina Mangiavillano, Benedetto Fantin, Alberto Rahal, Daoud Manfrin, Erminia Gavazzi, Francesca Bozzarelli, Silvia Crinò, Stefano Francesco Terrin, Maria Di Leo, Milena Bonifacio, Cristiana Facciorusso, Antonio Realdon, Stefano Cristofori, Chiara Auriemma, Francesco Fugazza, Alessandro Frulloni, Luca Hassan, Cesare Repici, Alessandro Carrara, Silvia |
author_facet | Spadaccini, Marco Conti Bellocchi, Maria Cristina Mangiavillano, Benedetto Fantin, Alberto Rahal, Daoud Manfrin, Erminia Gavazzi, Francesca Bozzarelli, Silvia Crinò, Stefano Francesco Terrin, Maria Di Leo, Milena Bonifacio, Cristiana Facciorusso, Antonio Realdon, Stefano Cristofori, Chiara Auriemma, Francesco Fugazza, Alessandro Frulloni, Luca Hassan, Cesare Repici, Alessandro Carrara, Silvia |
author_sort | Spadaccini, Marco |
collection | PubMed |
description | Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis. |
format | Online Article Text |
id | pubmed-10145689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101456892023-04-29 Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features Spadaccini, Marco Conti Bellocchi, Maria Cristina Mangiavillano, Benedetto Fantin, Alberto Rahal, Daoud Manfrin, Erminia Gavazzi, Francesca Bozzarelli, Silvia Crinò, Stefano Francesco Terrin, Maria Di Leo, Milena Bonifacio, Cristiana Facciorusso, Antonio Realdon, Stefano Cristofori, Chiara Auriemma, Francesco Fugazza, Alessandro Frulloni, Luca Hassan, Cesare Repici, Alessandro Carrara, Silvia J Clin Med Article Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis. MDPI 2023-04-12 /pmc/articles/PMC10145689/ /pubmed/37109171 http://dx.doi.org/10.3390/jcm12082829 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Spadaccini, Marco Conti Bellocchi, Maria Cristina Mangiavillano, Benedetto Fantin, Alberto Rahal, Daoud Manfrin, Erminia Gavazzi, Francesca Bozzarelli, Silvia Crinò, Stefano Francesco Terrin, Maria Di Leo, Milena Bonifacio, Cristiana Facciorusso, Antonio Realdon, Stefano Cristofori, Chiara Auriemma, Francesco Fugazza, Alessandro Frulloni, Luca Hassan, Cesare Repici, Alessandro Carrara, Silvia Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features |
title | Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features |
title_full | Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features |
title_fullStr | Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features |
title_full_unstemmed | Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features |
title_short | Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features |
title_sort | secondary tumors of the pancreas: a multicenter analysis of clinicopathological and endosonographic features |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145689/ https://www.ncbi.nlm.nih.gov/pubmed/37109171 http://dx.doi.org/10.3390/jcm12082829 |
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