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Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features

Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 20...

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Autores principales: Spadaccini, Marco, Conti Bellocchi, Maria Cristina, Mangiavillano, Benedetto, Fantin, Alberto, Rahal, Daoud, Manfrin, Erminia, Gavazzi, Francesca, Bozzarelli, Silvia, Crinò, Stefano Francesco, Terrin, Maria, Di Leo, Milena, Bonifacio, Cristiana, Facciorusso, Antonio, Realdon, Stefano, Cristofori, Chiara, Auriemma, Francesco, Fugazza, Alessandro, Frulloni, Luca, Hassan, Cesare, Repici, Alessandro, Carrara, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145689/
https://www.ncbi.nlm.nih.gov/pubmed/37109171
http://dx.doi.org/10.3390/jcm12082829
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author Spadaccini, Marco
Conti Bellocchi, Maria Cristina
Mangiavillano, Benedetto
Fantin, Alberto
Rahal, Daoud
Manfrin, Erminia
Gavazzi, Francesca
Bozzarelli, Silvia
Crinò, Stefano Francesco
Terrin, Maria
Di Leo, Milena
Bonifacio, Cristiana
Facciorusso, Antonio
Realdon, Stefano
Cristofori, Chiara
Auriemma, Francesco
Fugazza, Alessandro
Frulloni, Luca
Hassan, Cesare
Repici, Alessandro
Carrara, Silvia
author_facet Spadaccini, Marco
Conti Bellocchi, Maria Cristina
Mangiavillano, Benedetto
Fantin, Alberto
Rahal, Daoud
Manfrin, Erminia
Gavazzi, Francesca
Bozzarelli, Silvia
Crinò, Stefano Francesco
Terrin, Maria
Di Leo, Milena
Bonifacio, Cristiana
Facciorusso, Antonio
Realdon, Stefano
Cristofori, Chiara
Auriemma, Francesco
Fugazza, Alessandro
Frulloni, Luca
Hassan, Cesare
Repici, Alessandro
Carrara, Silvia
author_sort Spadaccini, Marco
collection PubMed
description Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis.
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spelling pubmed-101456892023-04-29 Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features Spadaccini, Marco Conti Bellocchi, Maria Cristina Mangiavillano, Benedetto Fantin, Alberto Rahal, Daoud Manfrin, Erminia Gavazzi, Francesca Bozzarelli, Silvia Crinò, Stefano Francesco Terrin, Maria Di Leo, Milena Bonifacio, Cristiana Facciorusso, Antonio Realdon, Stefano Cristofori, Chiara Auriemma, Francesco Fugazza, Alessandro Frulloni, Luca Hassan, Cesare Repici, Alessandro Carrara, Silvia J Clin Med Article Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary tumors of the pancreas referred to five Italian centers between 2010 and 2021. We described clinical and pathological features, therapeutic approach and treatment outcomes. EUS characteristics of the lesions and the tissue acquisition procedures (needle, passages, histology) were recorded. A total of 116 patients (males/females 69/47; mean age 66.7) with 236 histologically confirmed pancreatic metastases were included; kidney was the most common primary site. EUS was performed to confirm the diagnosis in 205 lesions which presented as predominantly solitary (59), hypoechoic (95) and hypervascular (60), with a heterogeneous (n = 54) pattern and well-defined borders (n = 52). EUS-guided tissue acquisition was performed in 94 patients with an overall accuracy of 97.9%. Histological evaluation was possible in 88.3% of patients, obtaining final diagnosis in all cases. When cytology alone was performed, the final diagnosis was obtained in 83.3% of cases. A total of 67 patients underwent chemo/radiation therapy, and surgery was attempted in 45 (38.8%) patients. Pancreatic metastases are a possible event in the natural history of solid tumors, even long after the diagnosis of the primary site. EUS-guided fine needle biopsy may be suggested to implement the differential diagnosis. MDPI 2023-04-12 /pmc/articles/PMC10145689/ /pubmed/37109171 http://dx.doi.org/10.3390/jcm12082829 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spadaccini, Marco
Conti Bellocchi, Maria Cristina
Mangiavillano, Benedetto
Fantin, Alberto
Rahal, Daoud
Manfrin, Erminia
Gavazzi, Francesca
Bozzarelli, Silvia
Crinò, Stefano Francesco
Terrin, Maria
Di Leo, Milena
Bonifacio, Cristiana
Facciorusso, Antonio
Realdon, Stefano
Cristofori, Chiara
Auriemma, Francesco
Fugazza, Alessandro
Frulloni, Luca
Hassan, Cesare
Repici, Alessandro
Carrara, Silvia
Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
title Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
title_full Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
title_fullStr Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
title_full_unstemmed Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
title_short Secondary Tumors of the Pancreas: A Multicenter Analysis of Clinicopathological and Endosonographic Features
title_sort secondary tumors of the pancreas: a multicenter analysis of clinicopathological and endosonographic features
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145689/
https://www.ncbi.nlm.nih.gov/pubmed/37109171
http://dx.doi.org/10.3390/jcm12082829
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