Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines

Horses and other equid species are frequently affected by bovine papillomavirus type 1 and/or 2 (BPV1, BPV2)-induced skin tumors termed sarcoids. Although sarcoids do not metastasize, they constitute a serious health problem due to their BPV1/2-mediated resistance to treatment and propensity to recr...

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Detalles Bibliográficos
Autores principales: Jindra, Christoph, Hainisch, Edmund K., Brandt, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145708/
https://www.ncbi.nlm.nih.gov/pubmed/37112681
http://dx.doi.org/10.3390/vaccines11040769
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author Jindra, Christoph
Hainisch, Edmund K.
Brandt, Sabine
author_facet Jindra, Christoph
Hainisch, Edmund K.
Brandt, Sabine
author_sort Jindra, Christoph
collection PubMed
description Horses and other equid species are frequently affected by bovine papillomavirus type 1 and/or 2 (BPV1, BPV2)-induced skin tumors termed sarcoids. Although sarcoids do not metastasize, they constitute a serious health problem due to their BPV1/2-mediated resistance to treatment and propensity to recrudesce in a more severe, multiple form following accidental or iatrogenic trauma. This review provides an overview on BPV1/2 infection and associated immune escape in the equid host and presents early and recent immunotherapeutic approaches in sarcoid management.
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spelling pubmed-101457082023-04-29 Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines Jindra, Christoph Hainisch, Edmund K. Brandt, Sabine Vaccines (Basel) Review Horses and other equid species are frequently affected by bovine papillomavirus type 1 and/or 2 (BPV1, BPV2)-induced skin tumors termed sarcoids. Although sarcoids do not metastasize, they constitute a serious health problem due to their BPV1/2-mediated resistance to treatment and propensity to recrudesce in a more severe, multiple form following accidental or iatrogenic trauma. This review provides an overview on BPV1/2 infection and associated immune escape in the equid host and presents early and recent immunotherapeutic approaches in sarcoid management. MDPI 2023-03-30 /pmc/articles/PMC10145708/ /pubmed/37112681 http://dx.doi.org/10.3390/vaccines11040769 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jindra, Christoph
Hainisch, Edmund K.
Brandt, Sabine
Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines
title Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines
title_full Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines
title_fullStr Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines
title_full_unstemmed Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines
title_short Immunotherapy of Equine Sarcoids—From Early Approaches to Innovative Vaccines
title_sort immunotherapy of equine sarcoids—from early approaches to innovative vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145708/
https://www.ncbi.nlm.nih.gov/pubmed/37112681
http://dx.doi.org/10.3390/vaccines11040769
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