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Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145713/ https://www.ncbi.nlm.nih.gov/pubmed/37111358 http://dx.doi.org/10.3390/ph16040601 |
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author | Wang, Hongna Zhu, Yidong Liu, Huiyan Liang, Tianxiang Wei, Yongjie |
author_facet | Wang, Hongna Zhu, Yidong Liu, Huiyan Liang, Tianxiang Wei, Yongjie |
author_sort | Wang, Hongna |
collection | PubMed |
description | Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. However, breakthroughs in R&D still await a deeper understanding of the underlying mechanisms and processes of how abnormalities in these membrane proteins induce related diseases. In this article, we summarize the current progress, challenges, and prospects for developing therapeutics targeting lysosomal membrane proteins for the treatment of lysosomal-associated diseases. |
format | Online Article Text |
id | pubmed-10145713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101457132023-04-29 Advances in Drug Discovery Targeting Lysosomal Membrane Proteins Wang, Hongna Zhu, Yidong Liu, Huiyan Liang, Tianxiang Wei, Yongjie Pharmaceuticals (Basel) Review Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. However, breakthroughs in R&D still await a deeper understanding of the underlying mechanisms and processes of how abnormalities in these membrane proteins induce related diseases. In this article, we summarize the current progress, challenges, and prospects for developing therapeutics targeting lysosomal membrane proteins for the treatment of lysosomal-associated diseases. MDPI 2023-04-17 /pmc/articles/PMC10145713/ /pubmed/37111358 http://dx.doi.org/10.3390/ph16040601 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Hongna Zhu, Yidong Liu, Huiyan Liang, Tianxiang Wei, Yongjie Advances in Drug Discovery Targeting Lysosomal Membrane Proteins |
title | Advances in Drug Discovery Targeting Lysosomal Membrane Proteins |
title_full | Advances in Drug Discovery Targeting Lysosomal Membrane Proteins |
title_fullStr | Advances in Drug Discovery Targeting Lysosomal Membrane Proteins |
title_full_unstemmed | Advances in Drug Discovery Targeting Lysosomal Membrane Proteins |
title_short | Advances in Drug Discovery Targeting Lysosomal Membrane Proteins |
title_sort | advances in drug discovery targeting lysosomal membrane proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145713/ https://www.ncbi.nlm.nih.gov/pubmed/37111358 http://dx.doi.org/10.3390/ph16040601 |
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