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Advances in Drug Discovery Targeting Lysosomal Membrane Proteins

Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substa...

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Detalles Bibliográficos
Autores principales: Wang, Hongna, Zhu, Yidong, Liu, Huiyan, Liang, Tianxiang, Wei, Yongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145713/
https://www.ncbi.nlm.nih.gov/pubmed/37111358
http://dx.doi.org/10.3390/ph16040601
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author Wang, Hongna
Zhu, Yidong
Liu, Huiyan
Liang, Tianxiang
Wei, Yongjie
author_facet Wang, Hongna
Zhu, Yidong
Liu, Huiyan
Liang, Tianxiang
Wei, Yongjie
author_sort Wang, Hongna
collection PubMed
description Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. However, breakthroughs in R&D still await a deeper understanding of the underlying mechanisms and processes of how abnormalities in these membrane proteins induce related diseases. In this article, we summarize the current progress, challenges, and prospects for developing therapeutics targeting lysosomal membrane proteins for the treatment of lysosomal-associated diseases.
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spelling pubmed-101457132023-04-29 Advances in Drug Discovery Targeting Lysosomal Membrane Proteins Wang, Hongna Zhu, Yidong Liu, Huiyan Liang, Tianxiang Wei, Yongjie Pharmaceuticals (Basel) Review Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. However, breakthroughs in R&D still await a deeper understanding of the underlying mechanisms and processes of how abnormalities in these membrane proteins induce related diseases. In this article, we summarize the current progress, challenges, and prospects for developing therapeutics targeting lysosomal membrane proteins for the treatment of lysosomal-associated diseases. MDPI 2023-04-17 /pmc/articles/PMC10145713/ /pubmed/37111358 http://dx.doi.org/10.3390/ph16040601 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Hongna
Zhu, Yidong
Liu, Huiyan
Liang, Tianxiang
Wei, Yongjie
Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
title Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
title_full Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
title_fullStr Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
title_full_unstemmed Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
title_short Advances in Drug Discovery Targeting Lysosomal Membrane Proteins
title_sort advances in drug discovery targeting lysosomal membrane proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145713/
https://www.ncbi.nlm.nih.gov/pubmed/37111358
http://dx.doi.org/10.3390/ph16040601
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