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Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
Parkinson’s disease (PD) has become the second most common neurodegenerative condition following Alzheimer’s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145765/ https://www.ncbi.nlm.nih.gov/pubmed/37112154 http://dx.doi.org/10.3390/s23083807 |
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author | Kanellos, Foivos S. Tsamis, Konstantinos I. Rigas, Georgios Simos, Yannis V. Katsenos, Andreas P. Kartsakalis, Gerasimos Fotiadis, Dimitrios I. Vezyraki, Patra Peschos, Dimitrios Konitsiotis, Spyridon |
author_facet | Kanellos, Foivos S. Tsamis, Konstantinos I. Rigas, Georgios Simos, Yannis V. Katsenos, Andreas P. Kartsakalis, Gerasimos Fotiadis, Dimitrios I. Vezyraki, Patra Peschos, Dimitrios Konitsiotis, Spyridon |
author_sort | Kanellos, Foivos S. |
collection | PubMed |
description | Parkinson’s disease (PD) has become the second most common neurodegenerative condition following Alzheimer’s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in the best case scenario, expert neurologists evaluate disease progression using established rating scales and patient-reported questionnaires, which have interpretability issues and are subject to recall bias. In this context, artificial-intelligence-driven telehealth solutions, such as wearable devices, have the potential to improve patient care and support physicians to manage PD more effectively by monitoring patients in their familiar environment in an objective manner. In this study, we evaluate the validity of in-office clinical assessment using the MDS-UPDRS rating scale compared to home monitoring. Elaborating the results for 20 patients with Parkinson’s disease, we observed moderate to strong correlations for most symptoms (bradykinesia, rest tremor, gait impairment, and freezing of gait), as well as for fluctuating conditions (dyskinesia and OFF). In addition, we identified for the first time the existence of an index capable of remotely measuring patients’ quality of life. In summary, an in-office examination is only partially representative of most PD symptoms and cannot accurately capture daytime fluctuations and patients’ quality of life. |
format | Online Article Text |
id | pubmed-10145765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101457652023-04-29 Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? Kanellos, Foivos S. Tsamis, Konstantinos I. Rigas, Georgios Simos, Yannis V. Katsenos, Andreas P. Kartsakalis, Gerasimos Fotiadis, Dimitrios I. Vezyraki, Patra Peschos, Dimitrios Konitsiotis, Spyridon Sensors (Basel) Article Parkinson’s disease (PD) has become the second most common neurodegenerative condition following Alzheimer’s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in the best case scenario, expert neurologists evaluate disease progression using established rating scales and patient-reported questionnaires, which have interpretability issues and are subject to recall bias. In this context, artificial-intelligence-driven telehealth solutions, such as wearable devices, have the potential to improve patient care and support physicians to manage PD more effectively by monitoring patients in their familiar environment in an objective manner. In this study, we evaluate the validity of in-office clinical assessment using the MDS-UPDRS rating scale compared to home monitoring. Elaborating the results for 20 patients with Parkinson’s disease, we observed moderate to strong correlations for most symptoms (bradykinesia, rest tremor, gait impairment, and freezing of gait), as well as for fluctuating conditions (dyskinesia and OFF). In addition, we identified for the first time the existence of an index capable of remotely measuring patients’ quality of life. In summary, an in-office examination is only partially representative of most PD symptoms and cannot accurately capture daytime fluctuations and patients’ quality of life. MDPI 2023-04-07 /pmc/articles/PMC10145765/ /pubmed/37112154 http://dx.doi.org/10.3390/s23083807 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanellos, Foivos S. Tsamis, Konstantinos I. Rigas, Georgios Simos, Yannis V. Katsenos, Andreas P. Kartsakalis, Gerasimos Fotiadis, Dimitrios I. Vezyraki, Patra Peschos, Dimitrios Konitsiotis, Spyridon Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? |
title | Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? |
title_full | Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? |
title_fullStr | Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? |
title_full_unstemmed | Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? |
title_short | Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? |
title_sort | clinical evaluation in parkinson’s disease: is the golden standard shiny enough? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145765/ https://www.ncbi.nlm.nih.gov/pubmed/37112154 http://dx.doi.org/10.3390/s23083807 |
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