Cargando…

Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?

Parkinson’s disease (PD) has become the second most common neurodegenerative condition following Alzheimer’s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanellos, Foivos S., Tsamis, Konstantinos I., Rigas, Georgios, Simos, Yannis V., Katsenos, Andreas P., Kartsakalis, Gerasimos, Fotiadis, Dimitrios I., Vezyraki, Patra, Peschos, Dimitrios, Konitsiotis, Spyridon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145765/
https://www.ncbi.nlm.nih.gov/pubmed/37112154
http://dx.doi.org/10.3390/s23083807
_version_ 1785034415505670144
author Kanellos, Foivos S.
Tsamis, Konstantinos I.
Rigas, Georgios
Simos, Yannis V.
Katsenos, Andreas P.
Kartsakalis, Gerasimos
Fotiadis, Dimitrios I.
Vezyraki, Patra
Peschos, Dimitrios
Konitsiotis, Spyridon
author_facet Kanellos, Foivos S.
Tsamis, Konstantinos I.
Rigas, Georgios
Simos, Yannis V.
Katsenos, Andreas P.
Kartsakalis, Gerasimos
Fotiadis, Dimitrios I.
Vezyraki, Patra
Peschos, Dimitrios
Konitsiotis, Spyridon
author_sort Kanellos, Foivos S.
collection PubMed
description Parkinson’s disease (PD) has become the second most common neurodegenerative condition following Alzheimer’s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in the best case scenario, expert neurologists evaluate disease progression using established rating scales and patient-reported questionnaires, which have interpretability issues and are subject to recall bias. In this context, artificial-intelligence-driven telehealth solutions, such as wearable devices, have the potential to improve patient care and support physicians to manage PD more effectively by monitoring patients in their familiar environment in an objective manner. In this study, we evaluate the validity of in-office clinical assessment using the MDS-UPDRS rating scale compared to home monitoring. Elaborating the results for 20 patients with Parkinson’s disease, we observed moderate to strong correlations for most symptoms (bradykinesia, rest tremor, gait impairment, and freezing of gait), as well as for fluctuating conditions (dyskinesia and OFF). In addition, we identified for the first time the existence of an index capable of remotely measuring patients’ quality of life. In summary, an in-office examination is only partially representative of most PD symptoms and cannot accurately capture daytime fluctuations and patients’ quality of life.
format Online
Article
Text
id pubmed-10145765
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101457652023-04-29 Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough? Kanellos, Foivos S. Tsamis, Konstantinos I. Rigas, Georgios Simos, Yannis V. Katsenos, Andreas P. Kartsakalis, Gerasimos Fotiadis, Dimitrios I. Vezyraki, Patra Peschos, Dimitrios Konitsiotis, Spyridon Sensors (Basel) Article Parkinson’s disease (PD) has become the second most common neurodegenerative condition following Alzheimer’s disease (AD), exhibiting high prevalence and incident rates. Current care strategies for PD patients include brief appointments, which are sparsely allocated, at outpatient clinics, where, in the best case scenario, expert neurologists evaluate disease progression using established rating scales and patient-reported questionnaires, which have interpretability issues and are subject to recall bias. In this context, artificial-intelligence-driven telehealth solutions, such as wearable devices, have the potential to improve patient care and support physicians to manage PD more effectively by monitoring patients in their familiar environment in an objective manner. In this study, we evaluate the validity of in-office clinical assessment using the MDS-UPDRS rating scale compared to home monitoring. Elaborating the results for 20 patients with Parkinson’s disease, we observed moderate to strong correlations for most symptoms (bradykinesia, rest tremor, gait impairment, and freezing of gait), as well as for fluctuating conditions (dyskinesia and OFF). In addition, we identified for the first time the existence of an index capable of remotely measuring patients’ quality of life. In summary, an in-office examination is only partially representative of most PD symptoms and cannot accurately capture daytime fluctuations and patients’ quality of life. MDPI 2023-04-07 /pmc/articles/PMC10145765/ /pubmed/37112154 http://dx.doi.org/10.3390/s23083807 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanellos, Foivos S.
Tsamis, Konstantinos I.
Rigas, Georgios
Simos, Yannis V.
Katsenos, Andreas P.
Kartsakalis, Gerasimos
Fotiadis, Dimitrios I.
Vezyraki, Patra
Peschos, Dimitrios
Konitsiotis, Spyridon
Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
title Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
title_full Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
title_fullStr Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
title_full_unstemmed Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
title_short Clinical Evaluation in Parkinson’s Disease: Is the Golden Standard Shiny Enough?
title_sort clinical evaluation in parkinson’s disease: is the golden standard shiny enough?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145765/
https://www.ncbi.nlm.nih.gov/pubmed/37112154
http://dx.doi.org/10.3390/s23083807
work_keys_str_mv AT kanellosfoivoss clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT tsamiskonstantinosi clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT rigasgeorgios clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT simosyannisv clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT katsenosandreasp clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT kartsakalisgerasimos clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT fotiadisdimitriosi clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT vezyrakipatra clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT peschosdimitrios clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough
AT konitsiotisspyridon clinicalevaluationinparkinsonsdiseaseisthegoldenstandardshinyenough