Cargando…
Association study of selenium-related gene polymorphisms with geriatric depression in China
Depression is a common mental health problem in older adults, but its cause remains unclear. Selenium is an essential micronutrient and a powerful antioxidant in the brain and nervous system. Several recent studies have reported a relationship between selenium levels and depression. This study aimed...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145890/ https://www.ncbi.nlm.nih.gov/pubmed/37115082 http://dx.doi.org/10.1097/MD.0000000000033594 |
_version_ | 1785034446777352192 |
---|---|
author | Liu, Yu Wang, Liqun Wang, Zhizhong He, Shulan |
author_facet | Liu, Yu Wang, Liqun Wang, Zhizhong He, Shulan |
author_sort | Liu, Yu |
collection | PubMed |
description | Depression is a common mental health problem in older adults, but its cause remains unclear. Selenium is an essential micronutrient and a powerful antioxidant in the brain and nervous system. Several recent studies have reported a relationship between selenium levels and depression. This study aimed to investigate the relationship between 4 genes co-associated with selenium and geriatric depression. 1486 participants were included in this study from 5 communities in Ningxia Hui Autonomous Region during 2013 to 2016 in a health examination program for urban and rural residents. Polymorphisms of 4 selenium-related genes were analyzed in 1266 healthy volunteers and 220 patients with depression. The genotyping of rs2830072, rs2030324, rs6265, rs11136000, rs7982, rs10510412, rs1801282, rs1151999, rs17793951, rs709149, rs709154, and rs4135263 were performed by Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS) technology. The analysis of selenium-related genes showed that there were significant differences between depression and controls for allele and genotype frequencies of peroxisome proliferator activated receptor gamma (PPARG) rs10510412, rs709149, and rs709154 (all P < .05). In this study, when adjusting for age, sex, marital status, education, and alcohol consumption, results showed that rs709149 and rs709154 were still significantly correlated with geriatric depression in the codominant, dominant, overdominant, and log-additive models. Logistic regression analysis showed that rs709149 AG or GG gene carriers were 1.630 and 1.746 times more susceptible to depression than AA gene carriers (95% CI = 1.042–2.549; 1.207–2.526). The results of this study suggest that the rs709149 polymorphism of the selenium-related gene PPARG is a genetic risk factor for depression in older adults. |
format | Online Article Text |
id | pubmed-10145890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101458902023-04-29 Association study of selenium-related gene polymorphisms with geriatric depression in China Liu, Yu Wang, Liqun Wang, Zhizhong He, Shulan Medicine (Baltimore) 4600 Depression is a common mental health problem in older adults, but its cause remains unclear. Selenium is an essential micronutrient and a powerful antioxidant in the brain and nervous system. Several recent studies have reported a relationship between selenium levels and depression. This study aimed to investigate the relationship between 4 genes co-associated with selenium and geriatric depression. 1486 participants were included in this study from 5 communities in Ningxia Hui Autonomous Region during 2013 to 2016 in a health examination program for urban and rural residents. Polymorphisms of 4 selenium-related genes were analyzed in 1266 healthy volunteers and 220 patients with depression. The genotyping of rs2830072, rs2030324, rs6265, rs11136000, rs7982, rs10510412, rs1801282, rs1151999, rs17793951, rs709149, rs709154, and rs4135263 were performed by Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS) technology. The analysis of selenium-related genes showed that there were significant differences between depression and controls for allele and genotype frequencies of peroxisome proliferator activated receptor gamma (PPARG) rs10510412, rs709149, and rs709154 (all P < .05). In this study, when adjusting for age, sex, marital status, education, and alcohol consumption, results showed that rs709149 and rs709154 were still significantly correlated with geriatric depression in the codominant, dominant, overdominant, and log-additive models. Logistic regression analysis showed that rs709149 AG or GG gene carriers were 1.630 and 1.746 times more susceptible to depression than AA gene carriers (95% CI = 1.042–2.549; 1.207–2.526). The results of this study suggest that the rs709149 polymorphism of the selenium-related gene PPARG is a genetic risk factor for depression in older adults. Lippincott Williams & Wilkins 2023-04-25 /pmc/articles/PMC10145890/ /pubmed/37115082 http://dx.doi.org/10.1097/MD.0000000000033594 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 4600 Liu, Yu Wang, Liqun Wang, Zhizhong He, Shulan Association study of selenium-related gene polymorphisms with geriatric depression in China |
title | Association study of selenium-related gene polymorphisms with geriatric depression in China |
title_full | Association study of selenium-related gene polymorphisms with geriatric depression in China |
title_fullStr | Association study of selenium-related gene polymorphisms with geriatric depression in China |
title_full_unstemmed | Association study of selenium-related gene polymorphisms with geriatric depression in China |
title_short | Association study of selenium-related gene polymorphisms with geriatric depression in China |
title_sort | association study of selenium-related gene polymorphisms with geriatric depression in china |
topic | 4600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145890/ https://www.ncbi.nlm.nih.gov/pubmed/37115082 http://dx.doi.org/10.1097/MD.0000000000033594 |
work_keys_str_mv | AT liuyu associationstudyofseleniumrelatedgenepolymorphismswithgeriatricdepressioninchina AT wangliqun associationstudyofseleniumrelatedgenepolymorphismswithgeriatricdepressioninchina AT wangzhizhong associationstudyofseleniumrelatedgenepolymorphismswithgeriatricdepressioninchina AT heshulan associationstudyofseleniumrelatedgenepolymorphismswithgeriatricdepressioninchina |