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A Review of the Bacterial Phosphoproteomes of Beneficial Microbes

The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority...

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Detalles Bibliográficos
Autor principal: Lim, Sooa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145908/
https://www.ncbi.nlm.nih.gov/pubmed/37110354
http://dx.doi.org/10.3390/microorganisms11040931
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author Lim, Sooa
author_facet Lim, Sooa
author_sort Lim, Sooa
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description The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species.
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spelling pubmed-101459082023-04-29 A Review of the Bacterial Phosphoproteomes of Beneficial Microbes Lim, Sooa Microorganisms Review The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species. MDPI 2023-04-03 /pmc/articles/PMC10145908/ /pubmed/37110354 http://dx.doi.org/10.3390/microorganisms11040931 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lim, Sooa
A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
title A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
title_full A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
title_fullStr A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
title_full_unstemmed A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
title_short A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
title_sort review of the bacterial phosphoproteomes of beneficial microbes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145908/
https://www.ncbi.nlm.nih.gov/pubmed/37110354
http://dx.doi.org/10.3390/microorganisms11040931
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