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A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145908/ https://www.ncbi.nlm.nih.gov/pubmed/37110354 http://dx.doi.org/10.3390/microorganisms11040931 |
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author | Lim, Sooa |
author_facet | Lim, Sooa |
author_sort | Lim, Sooa |
collection | PubMed |
description | The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species. |
format | Online Article Text |
id | pubmed-10145908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101459082023-04-29 A Review of the Bacterial Phosphoproteomes of Beneficial Microbes Lim, Sooa Microorganisms Review The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species. MDPI 2023-04-03 /pmc/articles/PMC10145908/ /pubmed/37110354 http://dx.doi.org/10.3390/microorganisms11040931 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lim, Sooa A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
title | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
title_full | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
title_fullStr | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
title_full_unstemmed | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
title_short | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
title_sort | review of the bacterial phosphoproteomes of beneficial microbes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145908/ https://www.ncbi.nlm.nih.gov/pubmed/37110354 http://dx.doi.org/10.3390/microorganisms11040931 |
work_keys_str_mv | AT limsooa areviewofthebacterialphosphoproteomesofbeneficialmicrobes AT limsooa reviewofthebacterialphosphoproteomesofbeneficialmicrobes |