Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression

Aurora A plays a critical role in G(2)/M transition and mitosis, making it an attractive target for cancer treatment. Aurora A inhibitors showed remarkable antitumor effects in preclinical studies, but unsatisfactory outcomes in clinical trials have greatly limited their development. In this study,...

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Detalles Bibliográficos
Autores principales: Wang, Xiaobo, Huang, Jing, Liu, Fenglin, Yu, Qian, Wang, Ruina, Wang, Jiaqi, Zhu, Zewen, Yu, Juan, Hou, Jun, Shim, Joong Sup, Jiang, Wei, Li, Zengxia, Zhang, Yuanyuan, Dang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145933/
https://www.ncbi.nlm.nih.gov/pubmed/36928177
http://dx.doi.org/10.1172/JCI161929

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