iPSC–derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function

Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an extremely heterogeneous genetic architecture, lending itself...

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Detalles Bibliográficos
Autores principales: Eade, Kevin T., Ansell, Brendan Robert E., Giles, Sarah, Fallon, Regis, Harkins-Perry, Sarah, Nagasaki, Takayuki, Tzaridis, Simone, Wallace, Martina, Mills, Elizabeth A., Farashi, Samaneh, Johnson, Alec, Sauer, Lydia, Hart, Barbara, Diaz-Rubio, M. Elena, Bahlo, Melanie, Metallo, Christian, Allikmets, Rando, Gantner, Marin L., Bernstein, Paul S., Friedlander, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145939/
https://www.ncbi.nlm.nih.gov/pubmed/37115691
http://dx.doi.org/10.1172/JCI163771

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